LINC01139 promotes phosphorylation of HIF1A by PTK6

Stable Identifier
R-HSA-8857583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PTK6 (BRK) tyrosine kinase, activated via long non-coding RNA LINC01139 (LINK-A) mediated recruitment to phosphorylated GPNMB (bound to HBEGF-activated EGFR), phosphorylates hypoxia inducible factor 1 alpha (HIF1A) at tyrosine residue Y565. Phosphorylation of HIF1A by PTK6 at Y565 inhibits HIF1A hydroxylation at proline P564, resulting in HIF1A stabilization under normoxic conditions (Lin et al. 2016).

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH

Nat. Cell Biol. 2016
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!