Reactome | ACVRL1 binds BMP9,BMP10

ACVRL1 binds BMP9,BMP10

Stable Identifier

R-HSA-8858369

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Growth/differentiation factor 2 (Bone morphogenic protein 9, BMP9, GDF2) and Bone morphogenetic protein 10 (BMP10) bind with sub-nanomolar affinities to both the type I receptor Serine/threonine-protein kinase receptor R3 (ACVRL1, Activin receptor-like kinase 1, ALK1) and the type II receptor Activin receptor type-2B (ActR-IIB, ACVR2B) (Scharpfenecker et al. 2007, Laurent et al. 2007, Townson et al. 2012). BMP9 also bind with high affinity the type II receptors Bone morphogenetic protein receptor type-2 (BMPR2) and Activin receptor type-2A (ACVR2A, ActRIIA) (Kuo et al. 2014; Kienast et al. 2016). BMP9 binding leads to phosphorylation of Mothers against decapentaplegic homolog 1 (SMAD1), SMAD5 and SMAD8 in microvascular endothelial cells (David et al. 2007).

ACVRL1 is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis (Massague 1998).

Literature References

PubMed ID	Title	Journal	Year
17311849	BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis Scharpfenecker, M, van Bezooijen, RL, Pukac, L, van Dinther, M, ten Dijke, P, Liu, Z, Löwik, CW, Zhao, Q	J. Cell. Sci.	2007
17068149	Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells Feige, JJ, Mallet, C, Mazerbourg, S, David, L, Bailly, S	Blood	2007