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FCAMR binds IgA
Stable Identifier
R-HSA-8858428
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
FCAMR binds IgA (Homo sapiens)
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IgA nephropathy (IgAN), the most common glomerulonephritis, is characterized by the deposition of IgA immune complexes in the glomerular mesangium. This is the result of High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (FCAMR, CD351) binding to IgA (McDonald et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
11779189
Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy
Jardine, AG
,
Cameron, AJ
,
Allen, JM
,
McDonald, KJ
Biochem. Biophys. Res. Commun.
2002
Participants
Input
2xIgA:JCHAIN [extracellular region]
(Homo sapiens)
FCAMR [plasma membrane]
(Homo sapiens)
Output
FCAMR:2xIgA:JCHAIN [plasma membrane]
(Homo sapiens)
Participates
as an event of
Cell surface interactions at the vascular wall (Homo sapiens)
Orthologous Events
FCAMR binds IgA (Bos taurus)
FCAMR binds IgA (Canis familiaris)
FCAMR binds IgA (Gallus gallus)
FCAMR binds IgA (Mus musculus)
FCAMR binds IgA (Rattus norvegicus)
FCAMR binds IgA (Sus scrofa)
Authored
Garapati, P V (2016-02-19)
Reviewed
Meldal, BH (2016-09-14)
Created
Garapati, P V (2016-02-19)
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