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P2RX4 [plasma membrane]
Stable Identifier
R-HSA-8861878
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2X purinoceptor 4, P2RX4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ATP binds P2RX4,7 (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
ATP:P2X4,7 trimer [plasma membrane] (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Binding of ATP to P2X receptors (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
P2X1-mediated entry of Ca++ from plasma (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99571 P2RX4
Gene Names
P2RX4
Chain
chain:1-388
Reference Genes
BioGPS Gene:5025 P2RX4
COSMIC (genes):P2RX4 P2RX4
CTD Gene:5025 P2RX4
dbSNP Gene:5025 P2RX4
ENSEMBL:ENSG00000135124 P2RX4
HGNC:8535 P2RX4
Monarch:5025 P2RX4
NCBI Gene:5025 P2RX4
OMIM:600846 P2RX4
UCSC:Q99571 P2RX4
Reference Transcript
RefSeq:NM_002560.2 P2RX4
RefSeq:NM_001261397.1 P2RX4
RefSeq:NM_001256796.1 P2RX4
Other Identifiers
11719483_a_at
11748548_a_at
16758075
204088_PM_at
204088_at
3434761
3434762
3434763
3434764
3434765
3434768
3434769
3434770
3434771
3434772
3434773
3434774
3434775
3434778
3434779
3434780
3434781
3434786
3434787
3434788
3434789
3434790
3434791
3434792
3434793
3434794
3434795
3434796
38332_at
5025
7959267
AF000234_at
A_14_P109562
A_23_P53623
A_33_P3362088
GE59497
GO:0001614
GO:0001894
GO:0002028
GO:0002931
GO:0003012
GO:0004931
GO:0005102
GO:0005215
GO:0005216
GO:0005507
GO:0005515
GO:0005524
GO:0005764
GO:0005765
GO:0005773
GO:0005886
GO:0006811
GO:0007165
GO:0008217
GO:0008270
GO:0010524
GO:0010614
GO:0015267
GO:0016020
GO:0019228
GO:0019233
GO:0019722
GO:0030054
GO:0030424
GO:0030425
GO:0032308
GO:0033198
GO:0034220
GO:0034405
GO:0035381
GO:0035590
GO:0042118
GO:0042802
GO:0043025
GO:0043195
GO:0043197
GO:0043226
GO:0043536
GO:0044297
GO:0045296
GO:0045429
GO:0048266
GO:0048471
GO:0048678
GO:0050850
GO:0050877
GO:0050920
GO:0050975
GO:0051897
GO:0051899
GO:0051928
GO:0055085
GO:0055117
GO:0055119
GO:0060079
GO:0060089
GO:0070062
GO:0070588
GO:0071294
GO:0071318
GO:0097190
GO:0098655
GO:0098662
GO:0098688
GO:0098839
GO:0098978
GO:0099604
GO:1904141
GO:2001028
HMNXSV003015402
HMNXSV003016840
ILMN_1813846
PH_hs_0032657
TC12000956.hg
TC12002619.hg
g4505548_3p_at
Participates
as a member of
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
Inferred To
P2RX4 [plasma membrane]
(Bos taurus)
P2RX4 [plasma membrane]
(Canis familiaris)
P2RX4 [plasma membrane]
(Danio rerio)
P2RX4 [plasma membrane]
(Gallus gallus)
P2RX4 [plasma membrane]
(Mus musculus)
P2RX4 [plasma membrane]
(Rattus norvegicus)
P2RX4 [plasma membrane]
(Sus scrofa)
P2RX4 [plasma membrane]
(Xenopus tropicalis)
p2xE [plasma membrane]
(Dictyostelium discoideum)
Cross References
ZINC - World Drugs
P2RX4_HUMAN
Guide to Pharmacology - Targets
481
ENSEMBL
ENST00000337233
,
ENSP00000438329
,
ENSP00000336607
,
ENST00000359949
,
ENSP00000353032
,
ENST00000542067
OpenTargets
ENSG00000135124
ZINC - FDA approved
P2RX4_HUMAN
ZINC - Substances
P2RX4_HUMAN
ZINC - Biogenic
P2RX4_HUMAN
ZINC target
Q99571
PRO
Q99571
GlyGen
Q99571
ZINC - Investigational
P2RX4_HUMAN
ZINC - Metabolites
P2RX4_HUMAN
HPA
ENSG00000135124-P2RX4
Pharos - Targets
Q99571
ZINC - Predictions - Purchasable
P2RX4_HUMAN
HMDB Protein
HMDBP14069
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q10472 GALNT1
3
GALNT1(1-559) [endoplasmic reticulum membrane]
(R-HSA-8849320)
GALNT1(1-559) [Golgi membrane]
(R-HSA-913698)
GALNT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9682906)
0.527
3
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