HSD17B2 oxidises estradiol (E2) to estrone (E1)

Stable Identifier
R-HSA-8862137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).

Literature References
PubMed ID Title Journal Year
26230928 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

Gargano, EM, Allegretta, G, Perspicace, E, Carotti, A, Van Koppen, C, Frotscher, M, Marchais-Oberwinkler, S, Hartmann, RW

PLoS ONE 2015
9783542 17Beta-hydroxysteroid dehydrogenases in human bone cells

Dong, Y, Qiu, QQ, Debear, J, Lathrop, WF, Bertolini, DR, Tamburini, PP

J. Bone Miner. Res. 1998
8099587 Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Wu, L, Einstein, M, Geissler, WM, Chan, HK, Elliston, KO, Andersson, S

J. Biol. Chem. 1993
Participants
Participates
Catalyst Activity

estradiol 17-beta-dehydrogenase activity of HSD17B2 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
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