USP48 cleaves polyubiquitin

Stable Identifier
R-HSA-8862184
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP48 cleaves polyubiquitin
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USP48 (confusingly referred to as USP31 in some literature) is a deubiquitinating enzyme that cleaves preferentially lysine-63-linked polyubiquitin chains. USP48 can also cleave lysine-48-linked polyubiquitin chains albeit to a lesser extent. USP48 can interact with TRAF2, and overexpression of USP48 inhibits NF-?B activation suggesting that it may remove ubiquitin from TRAF2, TRAF6 or another essential intermediate that lies downstream of TRAFs.
Literature References
PubMed ID Title Journal Year
16214042 Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB

Kieff, E, Arsenakis, M, Hatzivassiliou, EG, Michailidou, G, Mosialos, G, Tzimas, C

Cell. Signal. 2006
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Output
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Catalyst Activity

cysteine-type deubiquitinase activity of USP48:K63polyUb-TRAF2 [nucleoplasm]

Physical Entity
USP48:K63polyUb-TRAF2 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP48 cleaves polyubiquitin (Bos taurus)
USP48 cleaves polyubiquitin (Canis familiaris)
USP48 cleaves polyubiquitin (Gallus gallus)
USP48 cleaves polyubiquitin (Mus musculus)
USP48 cleaves polyubiquitin (Rattus norvegicus)
USP48 cleaves polyubiquitin (Sus scrofa)
USP48 cleaves polyubiquitin (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2016-02-25)
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