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VTI1B [platelet alpha granule lumen]
Stable Identifier
R-HSA-8862964
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Vesicle transport through interaction with t-SNAREs homolog 1B, VTI1B_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
VTI1B [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UEU0 VTI1B
Gene Names
VTI1B, VTI1, VTI1L, VTI1L1, VTI2
Chain
initiator methionine:, chain:2-232
Reference Genes
BioGPS Gene:10490 VTI1B
COSMIC (genes):VTI1B VTI1B
CTD Gene:10490 VTI1B
dbSNP Gene:10490 VTI1B
ENSEMBL:ENSG00000100568 VTI1B
ENSEMBL_homo_sapiens_GENE:ENSG00000100568.11 VTI1B
HGNC:17793 VTI1B
KEGG Gene (Homo sapiens):10490 VTI1B
Monarch:10490 VTI1B
NCBI Gene:10490 VTI1B
OMIM:603207 VTI1B
UCSC:Q9UEU0 VTI1B
Reference Transcript
RefSeq:NM_006370.2 VTI1B
Other Identifiers
10490
11733837_a_at
11759116_a_at
11763691_at
11763692_at
16794048
209452_PM_s_at
209452_s_at
225926_PM_at
225926_at
225928_PM_at
225928_at
2633574
2633576
2633580
2753936
32647_at
3569373
3569375
3569376
3569377
3569378
3569379
3569380
3569386
3569387
3569389
3569390
3569391
3569398
3569399
65555_at
75043_at
78110_at
78112_at
7979732
A_23_P14284
GE54561
GE85130
GO:0000149
GO:0005484
GO:0005515
GO:0005576
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006886
GO:0006891
GO:0006896
GO:0006904
GO:0006914
GO:0008021
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0016236
GO:0019869
GO:0031093
GO:0031201
GO:0031410
GO:0031901
GO:0031902
GO:0031982
GO:0042147
GO:0043025
GO:0043226
GO:0043231
GO:0048280
GO:0048471
GO:0055037
GO:0055038
GO:0060090
GO:0061024
GO:0061025
GO:0072659
GO:0098772
GO:1903076
HMNXSV003005197
HMNXSV003014662
Hs.172851.1.A1_3p_at
Hs.172851.1.A2_3p_at
ILMN_1693136
PH_hs_0019694
TC14002327.hg
g2687399_3p_s_at
Participates
as a member of
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
VTI1B [extracellular region]
Inferred To
vti1 [platelet alpha granule lumen]
(Schizosaccharomyces pombe)
vti1b [platelet alpha granule lumen]
(Danio rerio)
vti1b [platelet alpha granule lumen]
(Xenopus tropicalis)
LOC119866770 [platelet alpha granule lumen]
(Canis familiaris)
VTI1B [platelet alpha granule lumen]
(Bos taurus)
VTI1B [platelet alpha granule lumen]
(Dictyostelium discoideum)
VTI1B [platelet alpha granule lumen]
(Gallus gallus)
VTI1B [platelet alpha granule lumen]
(Plasmodium falciparum)
VTI1B [platelet alpha granule lumen]
(Sus scrofa)
VTI1 [platelet alpha granule lumen]
(Saccharomyces cerevisiae)
vti1B [platelet alpha granule lumen]
(Dictyostelium discoideum)
Homologues of VTI1B [platelet alpha granule lumen]
(Dictyostelium discoideum)
Homologues of VTI1B [platelet alpha granule lumen]
(Plasmodium falciparum)
Vti1b [platelet alpha granule lumen]
(Mus musculus)
Vti1b [platelet alpha granule lumen]
(Rattus norvegicus)
vti1A [platelet alpha granule lumen]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_006361.1
OpenTargets
ENSG00000100568
GeneCards
Q9UEU0
HPA
ENSG00000100568-VTI1B
Ensembl
ENSP00000450731
,
ENSG00000100568
,
ENST00000554659
PRO
Q9UEU0
Pharos - Targets
Q9UEU0
PDB
2V8S
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.725
6
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.718
6
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.643
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.618
10
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:Q9NRW7 VPS45
2
VPS45 [Golgi membrane]
(R-HSA-6811025)
VPS45 [endosome membrane]
(R-HSA-1011607)
0.527
2
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.527
2
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.527
3
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.527
2
UniProt:O75379 VAMP4
4
VAMP4 [transport vesicle]
(R-HSA-6811023)
VAMP4 [trans-Golgi network membrane]
(R-HSA-6811021)
VAMP4 [plasma membrane]
(R-HSA-8864461)
VAMP4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869133)
0.527
3
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.527
2
UniProt:Q9P2W9 STX18
1
STX18 [endoplasmic reticulum membrane]
(R-HSA-2029079)
0.527
2
UniProt:Q6UX04 CWC27
1
CWC27 [nucleoplasm]
(R-HSA-8867885)
0.527
2
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.527
2
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.527
2
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.527
2
UniProt:Q8WTR4 GDPD5
1
GDPD5 [endoplasmic reticulum membrane]
(R-HSA-6814136)
0.527
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.527
2
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.508
2
UniProt:Q14677 CLINT1
1
CLINT1 [cytosol]
(R-HSA-429811)
0.483
2
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