Reactome | ANXA5 [extracellular region]

ANXA5 [extracellular region]

Stable Identifier

R-HSA-8862986

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Annexin A5, ANXA5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08758 ANXA5

Gene Names

ANXA5, ANX5, ENX2, PP4

Chain

initiator methionine:, chain:2-320

Reference Genes

BioGPS Gene:308 ANXA5

COSMIC (genes):ANXA5 ANXA5

CTD Gene:308 ANXA5

dbSNP Gene:308 ANXA5

ENSEMBL:ENSG00000164111 ANXA5

HGNC:543 ANXA5

Monarch:308 ANXA5

NCBI Gene:308 ANXA5

OMIM:131230 ANXA5

UCSC:P08758 ANXA5

Reference Transcript

RefSeq:NM_001154.3 ANXA5

Other Identifiers

11743033_x_at

11750040_a_at

11750041_s_at

11750042_x_at

11756245_s_at

11759424_at

16979482

200782_PM_at

200782_at

2784036

2784037

2784038

2784039

2784040

2784041

2784042

2784043

2784044

2784045

2784046

2784047

2784048

2784049

2784050

2784051

2784057

2784058

2784059

2784060

2784062

2784063

2784064

2784065

2784066

2784068

2784070

2784071

2784072

308

37747_at

8102619

86469_at

A_23_P69720

GE57487

GE58246

GO:0001786

GO:0004859

GO:0005509

GO:0005515

GO:0005543

GO:0005544

GO:0005576

GO:0005737

GO:0005829

GO:0005886

GO:0005925

GO:0007165

GO:0007596

GO:0008289

GO:0009897

GO:0012506

GO:0016020

GO:0030312

GO:0031012

GO:0042383

GO:0042589

GO:0043066

GO:0043226

GO:0050819

GO:0062023

GO:0070062

GO:0072563

GO:0098772

HMNXSV003045131

ILMN_1741003

PH_hs_0022607

TC04001514.hg

TC04002701.hg

U01691_s_at

g4809273_3p_at

Participates

as a member of

Platelet releasate cytosolic proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

ANXA5 [cytosol]

Inferred To

AnxB10 [extracellular region] (Drosophila melanogaster)

Homologues of ANXA5 [extracellular region] (Dictyostelium discoideum)

Anxa5 [extracellular region] (Mus musculus)

Anxa5 [extracellular region] (Rattus norvegicus)

anxa5 [extracellular region] (Xenopus tropicalis)

nxnB [extracellular region] (Dictyostelium discoideum)

nxnA [extracellular region] (Dictyostelium discoideum)

anxa5b [extracellular region] (Danio rerio)

ANXA5 [extracellular region] (Bos taurus)

ANXA5 [extracellular region] (Canis familiaris)

ANXA5 [extracellular region] (Gallus gallus)

ANXA5 [extracellular region] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000296511, ENST00000296511

OpenTargets

ENSG00000164111

HPA

ENSG00000164111-ANXA5

PRO

P08758

Pharos - Targets

P08758

GlyGen

P08758

HMDB Protein

HMDBP02106

PDB

1HAK, 1HVE, 1AVH, 1HVD, 1HVF, 2XO2, 1SAV, 8H0J, 1HVG, 8H9Z, 2XO3, 1AVR, 1ANX, 6K25, 6K22, 1ANW, 8GYC

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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