p25-bound CDK5 phosphorylates CDC25B

Stable Identifier
R-HSA-8863007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CDK5, activated by binding to p25 phosphorylates CDC25B protein tyrosine phosphatase on serine and threonine residues S50, T69, S160, S321 and S470. In neurons, CDK25B localizes to both nucleus and cytosol and CDK5-mediated phosphorylation does not change its localization. Once activated by CDK5, CDC25B promotes activation of CDK1, CDK2 and CDK4 (Chang et al. 2012).
Literature References
PubMed ID Title Journal Year
22899714 Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Chang, KH, Vincent, F, Shah, K

J. Cell. Sci. 2012
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of CDK5:p25 [cytosol]

Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Created
Cite Us!