p25-bound CDK5 phosphorylates CDC25C

Stable Identifier
R-HSA-8863011
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p25-bound CDK5 phosphorylates CDC25C
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CDK5 activated by binding to p25 phosphorylates CDC25C protein tyrosine phosphatase at serine and threonine residues T48, T67, S122, T130, S168, and S214. CDK5-mediated phosphorylation of CDC25C interferes with 14-3-3-epsilon (YWHAE) mediated retention of CDC25C in the cytosol. Once activated by CDK5, CDC25C promotes activation of CDK1 (Chang et al. 2012).

Literature References
PubMed ID Title Journal Year
22899714 Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Chang, KH, Vincent, F, Shah, K

J. Cell. Sci. 2012
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Catalyst Activity

protein serine/threonine kinase activity of CDK5:p25 [cytosol]

Physical Entity
CDK5:p25 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-03-03)
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