Calpain-mediated cleavage of p35 to p25 is inhibited by calpastatin (CAST). CAST levels are decreased in Alzheimer disease (Sato et al. 2011).
Peng, J, Kwon, YT, Friedlander, RM, Lee, MS, Li, M, Tsai, LH
calcium-dependent cysteine-type endopeptidase activity of Calpain1, Calpain2:Ca2+ [plasma membrane]
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