p25-bound CDK5 phosphorylates CDC25A

Stable Identifier
R-HSA-8863014
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p25-bound CDK5 phosphorylates CDC25A
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CDK5, activated by binding to p25, phosphorylates CDC25A protein tyrosine phosphatase at serine residues S40, S116 and S261. CDC25A mainly localizes to the nucleus in neurons and CDK5-mediated phosphorylation does not change its localization. Once activated by CDK5, CDC25A promotes activation of CDK1, CDK2 and CDK4 (Chang et al. 2012).
Literature References
PubMed ID Title Journal Year
22899714 Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Chang, KH, Vincent, F, Shah, K

J. Cell. Sci. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]

Physical Entity
CDK5:p25 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-03-03)
Cite Us!