Reactome | SPPL2B [plasma membrane]

SPPL2B [plasma membrane]

Stable Identifier

R-HSA-8863116

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fullName evidence="14 17"Signal peptide peptidase-like 2B, SPP2B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TCT7 SPPL2B

Gene Names

SPPL2B, IMP4, KIAA1532, PSL1

Chain

signal peptide:1-25, chain:26-592

Reference Genes

BioGPS Gene:56928 SPPL2B

COSMIC (genes):IMP4 SPPL2B

COSMIC (genes):SPPL2B SPPL2B

CTD Gene:56928 SPPL2B

dbSNP Gene:56928 SPPL2B

ENSEMBL:ENSG00000005206 SPPL2B

HGNC:30627 SPPL2B

KEGG:hsa:56928 SPPL2B

Monarch:56928 SPPL2B

NCBI Gene:56928 SPPL2B

OMIM:608239 SPPL2B

UCSC:Q8TCT7 SPPL2B

Reference Transcript

Participates

as a member of

SPPL2A,SPPL2B [plasma membrane] (Homo sapiens)

Inferred To

Sppl2b [plasma membrane] (Mus musculus)

Sppl2b [plasma membrane] (Rattus norvegicus)

sppl2 [plasma membrane] (Danio rerio)

sppl2b [plasma membrane] (Xenopus tropicalis)

SPPL2B [plasma membrane] (Bos taurus)

SPPL2B [plasma membrane] (Canis familiaris)

SPPL2B [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001070706.1, NP_694533.1

ENSEMBL

ENSG00000005206, ENSP00000478510, ENST00000618220, ENSP00000480813, ENSP00000478298, ENST00000610743, ENST00000613503

OpenTargets

ENSG00000005206

GeneCards

SPPL2B

HPA

ENSG00000005206-SPPL2B

PRO

Q8TCT7

Pharos - Targets

Q8TCT7

GlyGen

Q8TCT7

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [Golgi membrane] (R-HSA-9817559) SLC30A5 [secretory granule membrane] (R-HSA-437105)	0.643	5
UniProt:Q9BY67 CADM1	1	CADM1 [plasma membrane] (R-HSA-420589)	0.643	4
UniProt:O95427 PIGN	1	PIGN [endoplasmic reticulum membrane] (R-HSA-162724)	0.643	5
UniProt:O75063 FAM20B	1	FAM20B [Golgi membrane] (R-HSA-9941363)	0.643	4
UniProt:Q9UBQ6 EXTL2	2	EXTL2 [Golgi membrane] (R-HSA-9941007) EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.527	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.527	2
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	4
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.527	2
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q7Z7B1 PIGW	1	PIGW [endoplasmic reticulum membrane] (R-HSA-162693)	0.527	2
UniProt:Q496F6 CD300E	1	CD300E [plasma membrane] (R-HSA-2130162)	0.527	2
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.527	3
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.527	2
UniProt:O43909 EXTL3	2	EXTL3 [Golgi membrane] (R-HSA-9941179) EXTL3 [endoplasmic reticulum membrane] (R-HSA-535476)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	3

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