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KBTBD8 [cytosol]
Stable Identifier
R-HSA-8863192
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch repeat and BTB domain-containing protein 8, KBTB8_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KBTBD8 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23578279
The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis
Lührig, S
,
Nolte, J
,
Kolb, S
,
Mellies, N
Cell Div
2013
External Reference Information
External Reference
UniProt:Q8NFY9 KBTBD8
Gene Names
KBTBD8, KIAA1842, TAKRP
Chain
chain:1-601
Reference Genes
BioGPS Gene:84541 KBTBD8
COSMIC (genes):KBTBD8 KBTBD8
CTD Gene:84541 KBTBD8
dbSNP Gene:84541 KBTBD8
ENSEMBL:ENSG00000163376 KBTBD8
ENSEMBL_homo_sapiens_GENE:ENSG00000163376.11 KBTBD8
HGNC:30691 KBTBD8
KEGG Gene (Homo sapiens):84541 KBTBD8
Monarch:84541 KBTBD8
NCBI Gene:84541 KBTBD8
OMIM:616607 KBTBD8
UCSC:Q8NFY9 KBTBD8
Reference Transcript
RefSeq:NM_032505.2 KBTBD8
Other Identifiers
11730011_at
11730012_s_at
16942511
239835_PM_at
239835_at
2628272
2628274
2628275
2628278
2628279
2628280
49753_at
66269_at
8080911
84541
A_14_P130861
A_14_P202466
A_23_P431252
GE656892
GO:0005515
GO:0005737
GO:0005794
GO:0005819
GO:0005829
GO:0005856
GO:0006417
GO:0006513
GO:0014029
GO:0014032
GO:0030154
GO:0031463
GO:0036211
GO:0043226
GO:0048856
HMNXSV003049212
Hs.116665.0.A1_3p_at
ILMN_1716272
PH_hs_0006392
TC03000407.hg
Participates
as a member of
BTB proteins [cytosol] (Homo sapiens)
Inferred To
kbtbd8 [cytosol]
(Danio rerio)
Kbtbd8 [cytosol]
(Mus musculus)
Kbtbd8 [cytosol]
(Rattus norvegicus)
Dm.CG15097 [cytosol]
(Drosophila melanogaster)
KBTBD8 [cytosol]
(Bos taurus)
KBTBD8 [cytosol]
(Canis familiaris)
KBTBD8 [cytosol]
(Dictyostelium discoideum)
KBTBD8 [cytosol]
(Gallus gallus)
KBTBD8 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_115894.2
OpenTargets
ENSG00000163376
GeneCards
Q8NFY9
HPA
ENSG00000163376-KBTBD8
Ensembl
ENSP00000419738
,
ENST00000460576
,
ENST00000417314
,
ENSP00000401878
,
ENSG00000163376
PRO
Q8NFY9
Pharos - Targets
Q8NFY9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.499
3
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