Reactome | KLHL2 [cytosol]

KLHL2 [cytosol]

Stable Identifier

R-HSA-8863217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch-like protein 2, KLHL2_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95198 KLHL2

Gene Names

KLHL2

Chain

chain:1-593

Reference Genes

BioGPS Gene:11275 KLHL2

COSMIC (genes):KLHL2 KLHL2

CTD Gene:11275 KLHL2

dbSNP Gene:11275 KLHL2

ENSEMBL:ENSG00000109466 KLHL2

HGNC:6353 KLHL2

KEGG:hsa:11275 KLHL2

Monarch:11275 KLHL2

NCBI Gene:11275 KLHL2

OMIM:605774 KLHL2

UCSC:O95198 KLHL2

Reference Transcript

Other Identifiers

11275

11724676_a_at

11748596_a_at

16972129

219157_PM_at

219157_at

2741300

2741301

2741303

2741307

2741313

2741314

2741321

2750539

2750540

2750541

2750542

2750544

2750547

2750548

2750550

2750554

2750555

2750561

2750562

2750565

2750566

2750567

2750570

2750573

2750576

2750577

2750578

2750580

2750583

2750585

2750586

2750587

2750588

76319_at

8098177

A_23_P72503

GE61646

GO:0001726

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0008092

GO:0015629

GO:0016020

GO:0016567

GO:0030027

GO:0031463

GO:0042802

GO:0042995

GO:0043226

GO:0060090

GO:1990756

HMNXSV003014648

HMNXSV003017873

ILMN_1701837

ILMN_1815405

PH_hs_0006888

TC04000826.hg

TC04002168.hg

g6005702_3p_at

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

Inferred To

kel-1 [cytosol] (Caenorhabditis elegans)

KLHL2 [cytosol] (Bos taurus)

KLHL2 [cytosol] (Canis familiaris)

KLHL2 [cytosol] (Dictyostelium discoideum)

KLHL2 [cytosol] (Gallus gallus)

KLHL2 [cytosol] (Sus scrofa)

Klhl2 [cytosol] (Mus musculus)

Klhl2 [cytosol] (Rattus norvegicus)

kel [cytosol] (Drosophila melanogaster)

klhl2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001154994.1, NP_001154993.1, NP_001317953.1, NP_001317952.1, NP_009177.3, XP_016863165.1

ENSEMBL

ENST00000226725, ENSP00000226725, ENST00000514860, ENSP00000424198, ENST00000538127, ENSP00000437526

OpenTargets

ENSG00000109466

HPA

ENSG00000109466-KLHL2

PRO

O95198

Pharos - Targets

O95198

GlyGen

O95198

PDB

2XN4, 4CHB

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.77	7
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q08273	3	RBX1 [nucleoplasm] (R-SCE-1234142) RNF7 (RBX2) [cytosol] (R-SCE-8863132) RBX1 [cytosol] (R-SCE-180582)	0.556	3
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	7

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