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KLHL5 [cytosol]
Stable Identifier
R-HSA-8863223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 5, KLHL5_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PQ7 KLHL5
Gene Names
KLHL5
Chain
chain:1-755
Reference Genes
BioGPS Gene:51088 KLHL5
COSMIC (genes):KLHL5 KLHL5
CTD Gene:51088 KLHL5
dbSNP Gene:51088 KLHL5
ENSEMBL:ENSG00000109790 KLHL5
HGNC:6356 KLHL5
KEGG:hsa:51088 KLHL5
Monarch:51088 KLHL5
NCBI Gene:51088 KLHL5
OMIM:608064 KLHL5
UCSC:Q96PQ7 KLHL5
Reference Transcript
RefSeq:NM_199039.3 KLHL5
RefSeq:NM_015990.4 KLHL5
RefSeq:NM_001007075.2 KLHL5
Other Identifiers
11728766_a_at
11728767_s_at
11728768_s_at
16966049
226001_PM_at
226001_at
227565_PM_at
227565_at
232297_PM_at
232297_at
233866_3p_at
233866_PM_at
233866_at
2724159
2724167
2724168
2724169
2724170
2724175
2724176
2724177
2724178
2724180
2724183
2724185
2724186
2724189
2724190
2724193
2724194
2724198
2724199
2724200
2724201
2724202
2724203
2724204
2724210
2724211
3939567
3939569
51088
61648_at
62506_at
8094625
A_14_P116354
A_14_P134979
A_23_P121527
A_24_P17710
A_24_P17719
A_24_P848714
GE62900
GE63078
GO:0003674
GO:0003779
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0008092
GO:0008150
GO:0043226
HMNXSV003014016
HMNXSV003028366
Hs.272239.1.S1_3p_at
Hs.272239.3.S1_3p_at
Hs.272251.0.S1_3p_at
Hs.29088.0.A1_3p_at
ILMN_1706687
ILMN_2258234
ILMN_2342437
PH_hs_0023361
TC04000224.hg
Participates
as a member of
BTB proteins [cytosol] (Homo sapiens)
Inferred To
klhl5 [cytosol]
(Xenopus tropicalis)
Dmel\CG17754 [cytosol]
(Drosophila melanogaster)
Klhl5 [cytosol]
(Mus musculus)
Klhl5 [cytosol]
(Rattus norvegicus)
KLHL5 [cytosol]
(Bos taurus)
KLHL5 [cytosol]
(Canis familiaris)
KLHL5 [cytosol]
(Dictyostelium discoideum)
KLHL5 [cytosol]
(Gallus gallus)
KLHL5 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_057074.3
,
NP_950240.2
,
NP_001007076.1
ENSEMBL
ENST00000261425
,
ENSP00000423897
,
ENST00000508137
,
ENST00000504108
,
ENSP00000423080
,
ENSP00000261425
OpenTargets
ENSG00000109790
HPA
ENSG00000109790-KLHL5
PRO
Q96PQ7
Pharos - Targets
Q96PQ7
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NYA1 SPHK1
4
SPHK1 [nucleoplasm]
(R-HSA-9836616)
p-S225-SPHK1 [nucleoplasm]
(R-HSA-9836613)
p-S225-SPHK1 [cytosol]
(R-HSA-5218716)
SPHK1 [cytosol]
(R-HSA-391267)
0.482
2
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