Reactome | CRBN [cytosol]

CRBN [cytosol]

Stable Identifier

R-HSA-8863300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein cereblon, CRBN_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13620 CUL4B

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        CRBN binds IMiDs (Homo sapiens)
        
        CRBN [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
26188093	Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction Yamada, H, Sawamura, N, Matsumoto, K, Asahi, T, Wakabayashi, S	Biochem. Biophys. Res. Commun.	2015

External Reference Information

External Reference

UniProt:Q96SW2 CRBN

Gene Names

CRBN, AD-006

Chain

chain:1-442

Reference Genes

BioGPS Gene:51185 CRBN

COSMIC (genes):CRBN CRBN

CTD Gene:51185 CRBN

dbSNP Gene:51185 CRBN

ENSEMBL:ENSG00000113851 CRBN

HGNC:30185 CRBN

KEGG:hsa:51185 CRBN

Monarch:51185 CRBN

NCBI Gene:51185 CRBN

OMIM:609262 CRBN

UCSC:Q96SW2 CRBN

Reference Transcript

Participates

as a component of

CRBN:IMiDs [cytosol] (Homo sapiens)

as an input of

CRBN binds IMiDs (Homo sapiens)

Cross References

Guide to Pharmacology - Targets

3086

OpenTargets

ENSG00000113851

ENSEMBL

ENSP00000412499, ENST00000432408, ENSP00000231948, ENST00000231948, ENSG00000113851

HPA

ENSG00000113851-CRBN

GeneCards

CRBN

PRO

Q96SW2

Pharos - Targets

Q96SW2

PDB

7BQU, 8D80, 4M91, 6XK9, 7BQV, 8D7Z, 7U8F, 8D81, 8D7Y, 8TNP, 8D7W, 8G66, 8OJH, 8D7X, 8UH6, 8RQ1, 9GAO, 6H0G, 8TNR, 8TNQ, 7LPS, 6H0F, 8D7U, 8OIZ, 8D7V, 9CUO, 8RQC, 8CVP, 5FQD, 5HXB, 8RQ9, 8RQ8, 5V3O, 8DEY, 6BNB, 8U17, 4TZ4, 6BOY, 8U15, 8TZX, 6BN9, 6BN8, 8U16, 6BN7, 8RQA, 6UML

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.723	4
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.666	4
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.648	6
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.648	4
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.641	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q96A83-2 Q96A832			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.528	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.528	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	5

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