Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDK5:p25 [cytosol]
Stable Identifier
R-HSA-8863434
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5 binds p25 (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 phosphorylates FOXO3 (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 phosphorylates JUN (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 phosphorylates PRDX2 (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:p25 translocates to the nucleus (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10830966
Neurotoxicity induces cleavage of p35 to p25 by calpain
Peng, J
,
Kwon, YT
,
Friedlander, RM
,
Lee, MS
,
Li, M
,
Tsai, LH
Nature
2000
Participants
components
CDK5 [cytosol]
(Homo sapiens)
CDK5R1(99-307) [cytosol]
(Homo sapiens)
Participates
as an output of
CDK5 binds p25 (Homo sapiens)
as an input of
CDK5:p25 translocates to the nucleus (Homo sapiens)
This entity regulates
Negatively
CDC25C binds YWHAE (14-3-3-epsilon)
(Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text