STON2 is neddylated

Stable Identifier
R-HSA-8863727
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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STON2 is neddylated
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STON2 is post-translationally neddylated by an unknown enzyme. Neddylation appears to contribute to STON2 destabilization, possibly by promoting its subsequent ubiquitination and degradation. Decreased STON2 protein levels are associated with increased plasma membrane levels of SYT1, reflecting a defect in its STON2-mediated recapture through endocytosis (Granata et al, 2011).
Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Warner, TT, Schiavo, G, Haucke, V, Koo, SJ

EMBO J. 2011
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Orthologous Events
STON2 is neddylated (Bos taurus)
STON2 is neddylated (Caenorhabditis elegans)
STON2 is neddylated (Canis familiaris)
STON2 is neddylated (Danio rerio)
STON2 is neddylated (Dictyostelium discoideum)
STON2 is neddylated (Drosophila melanogaster)
STON2 is neddylated (Gallus gallus)
STON2 is neddylated (Mus musculus)
STON2 is neddylated (Plasmodium falciparum)
STON2 is neddylated (Rattus norvegicus)
STON2 is neddylated (Saccharomyces cerevisiae)
STON2 is neddylated (Schizosaccharomyces pombe)
STON2 is neddylated (Sus scrofa)
Authored
Rothfels, K  (2016-05-11)
Reviewed
Antonescu, CN  (2016-05-10)
Created
Rothfels, K  (2016-03-10)
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