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CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-HSA-8863866
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Synonyms
calreticulin
Locations in the PathwayBrowser for interactor UniProt:O75175 CNOT3
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27797 CALR
Gene Names
CALR, CRTC
Chain
signal peptide:1-17, chain:18-417
Reference Genes
BioGPS Gene:811 CALR
COSMIC (genes):CALR CALR
CTD Gene:811 CALR
dbSNP Gene:811 CALR
ENSEMBL:ENSG00000179218 CALR
HGNC:1455 CALR
KEGG:hsa:811 CALR
Monarch:811 CALR
NCBI Gene:811 CALR
OMIM:109091 CALR
UCSC:P27797 CALR
Reference Transcript
RefSeq:NM_004343.3 CALR
Other Identifiers
11715374_a_at
11715375_x_at
16858774
1752_at
200935_PM_at
200935_at
212953_PM_x_at
212953_x_at
214315_PM_x_at
214315_x_at
32543_at
3822050
3822051
3822052
3822053
3822054
3822055
3822056
3822057
3822058
3822059
3822060
3822061
3822062
3822063
3822064
3822065
3822066
3822067
3822068
3822069
3822070
3822071
3822072
3822073
8026106
811
A_14_P107778
A_23_P67288
A_33_P3292854
GE79860
GO:0000122
GO:0001669
GO:0001849
GO:0002502
GO:0003677
GO:0003723
GO:0003729
GO:0005049
GO:0005178
GO:0005506
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005829
GO:0005840
GO:0005925
GO:0006355
GO:0006457
GO:0006611
GO:0006874
GO:0006886
GO:0006913
GO:0007010
GO:0007283
GO:0008270
GO:0008284
GO:0009410
GO:0009897
GO:0009986
GO:0010595
GO:0010628
GO:0012505
GO:0016020
GO:0016529
GO:0017148
GO:0022414
GO:0022417
GO:0030154
GO:0030163
GO:0030246
GO:0030312
GO:0030670
GO:0030866
GO:0031012
GO:0031410
GO:0031625
GO:0032355
GO:0032991
GO:0033018
GO:0033116
GO:0033144
GO:0033574
GO:0034504
GO:0034975
GO:0036503
GO:0040020
GO:0042277
GO:0042562
GO:0042824
GO:0042921
GO:0042981
GO:0043226
GO:0043231
GO:0044183
GO:0044194
GO:0044322
GO:0045665
GO:0045787
GO:0045892
GO:0046872
GO:0048387
GO:0048471
GO:0050681
GO:0050766
GO:0050821
GO:0051082
GO:0051087
GO:0051208
GO:0051604
GO:0055007
GO:0060473
GO:0062023
GO:0065003
GO:0070062
GO:0071257
GO:0071285
GO:0071682
GO:0090398
GO:0098553
GO:0098586
GO:0098794
GO:0098978
GO:0140104
GO:0140313
GO:1900026
GO:1901164
GO:1901224
GO:1901652
GO:1903416
GO:1904614
GO:2000510
HMNXSV003003743
HMNXSV003044478
Hs.16488.2.A1_3p_x_at
Hs.16488.3.A1_3p_x_at
ILMN_1736256
M84739_at
PH_hs_0017137
TC19000232.hg
g5921996_3p_a_at
Participates
as an output of
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
as an input of
SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
as a component of
CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
CALR [lumenal side of endoplasmic reticulum membrane]
CALR [endoplasmic reticulum lumen]
CALR [extracellular region]
CALR [endocytic vesicle lumen]
CALR [phagocytic vesicle membrane]
Inferred To
calr3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Danio rerio)
calr [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Xenopus tropicalis)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Bos taurus)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Caenorhabditis elegans)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Canis familiaris)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Dictyostelium discoideum)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Drosophila melanogaster)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Gallus gallus)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Mus musculus)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Rattus norvegicus)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004334.1
OpenTargets
ENSG00000179218
ENSEMBL
ENSP00000320866
,
ENST00000586967
,
ENSP00000466037
,
ENST00000316448
HPA
ENSG00000179218-CALR
PRO
P27797
Pharos - Targets
P27797
GlyGen
P27797
Orphanet
CALR
HMDB Protein
HMDBP07533
PDB
5LK5
,
3POS
,
8TZO
,
5V90
,
8TZR
,
3DOW
,
3POW
,
2CLR
,
6ENY
,
7QPD
Interactors (93)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.737
5
UniProt:O95166 GABARAP
3
GABARAP [cytosol]
(R-HSA-975521)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [autophagosome membrane]
(R-HSA-5683634)
0.71
4
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.659
3
UniProt:Q12824 SMARCB1
1
SMARCB1 [nucleoplasm]
(R-HSA-389261)
0.594
5
UniProt:P30101 PDIA3
3
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.589
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:Q68CL5-3 TPGS2
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q9NX07 TSAP1
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
IntAct:EBI-25833913 CCSB
0.556
3
UniProt:Q3SY56 SP6
0.556
3
IntAct:EBI-25831691 CCSB
0.556
3
UniProt:Q96E17 RAB3C
2
GGC-RAB3C [cytosol]
(R-HSA-8874012)
RAB3C [cytosol]
(R-HSA-8873684)
0.556
3
UniProt:Q9NVM1 EVA1B
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q7Z780 Q7Z780
0.556
3
UniProt:Q96GK7 FAH2A
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q9H2S6-2 TNMD
0.556
3
UniProt:Q96L03 SPT17
0.556
3
UniProt:F6Y2X3 F6Y2X3
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q8N1W1-4 ARHGEF28
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P14060 HSD3B1
1
HSD3B1 [endoplasmic reticulum membrane]
(R-HSA-192072)
0.556
3
UniProt:P79483 HLA-DRB3
9
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130513)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130432)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
(R-HSA-2214381)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
(R-HSA-2130452)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
(R-HSA-2130559)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130515)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
(R-HSA-2130377)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
(R-HSA-2130676)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(R-HSA-197577)
0.556
3
UniProt:Q6P4D5-2 PABIR3
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [nucleoplasm]
(R-HSA-2564700)
TPX2 [cytosol]
(R-HSA-8853407)
0.556
3
UniProt:Q6P5S2 LEG1H
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:O75317 USP12
1
USP12 [nucleoplasm]
(R-HSA-5696907)
0.556
3
IntAct:EBI-25834143 CCSB
0.556
3
IntAct:EBI-25833532 RZPDO839F06154
0.556
3
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.556
3
UniProt:Q13636 RAB31
5
GGC-RAB31 [early endosome membrane]
(R-HSA-8877278)
GGC-RAB31 [cytosol]
(R-HSA-8873974)
RAB31 [cytosol]
(R-HSA-8873690)
RAB31 [plasma membrane]
(R-HSA-6804813)
RAB31 [secretory granule membrane]
(R-HSA-6804797)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.556
3
UniProt:Q10981 FUT2
1
FUT2 [Golgi membrane]
(R-HSA-2980904)
0.556
3
UniProt:P61224 RAP1B
2
RAP1B [plasma membrane]
(R-HSA-377590)
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
0.556
3
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q53T94 TAF1B
2
TAF1B [nucleoplasm]
(R-HSA-73691)
Ac-TAF1B [nucleoplasm]
(R-HSA-5138530)
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8IY82 DRC7
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q96P20 NLRP3
2
NLRP3 [cytosol]
(R-HSA-561189)
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
0.556
3
IntAct:EBI-25833762 CCSB
0.556
3
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:P50749 RASF2
0.556
3
UniProt:Q8NCF5-2 NFATC2IP
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:O14829 PPEF1
1
PPEF1 [cytosol]
(R-HSA-2632517)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:Q9Y3Y4 PYGO1
1
PYGO1 [nucleoplasm]
(R-HSA-201705)
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:O00214-2 LGALS8
0.556
3
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:A0JP07 A0JP07
0.556
3
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.556
3
UniProt:Q96EY8 MMAB
4
MMAB E193K [mitochondrial matrix]
(R-HSA-3322150)
MMAB R191W [mitochondrial matrix]
(R-HSA-3322112)
MMAB R186W [mitochondrial matrix]
(R-HSA-3322128)
MMAB [mitochondrial matrix]
(R-HSA-2980970)
0.556
3
UniProt:P11226 MBL2
1
MBL2 [extracellular region]
(R-HSA-166674)
0.544
6
UniProt:P05111 INHA
1
INHA [extracellular region]
(R-HSA-1449702)
0.527
2
UniProt:O00755 WNT7A
9
WNT7A [extracellular region]
(R-HSA-517404)
N4GlycoAsn-PalmS WNT7A [extracellular exosome]
(R-HSA-3781951)
N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]
(R-HSA-3781961)
WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238312)
N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238249)
N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238354)
N4GlycoAsn-PalmS WNT7A [Golgi lumen]
(R-HSA-3247778)
N4GlycoAsn-PalmS WNT7A [extracellular region]
(R-HSA-3247774)
N4GlycoAsn-PalmS WNT7A [plasma membrane]
(R-HSA-3247833)
0.527
2
UniProt:Q6FHJ7 SFRP4
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P12644 BMP4
4
BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956775)
p-BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956944)
BMP4 [extracellular region]
(R-HSA-8858573)
BMP4(20-408) [extracellular region]
(R-HSA-2396280)
0.527
2
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.508
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q03518 TAP1
3
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
4
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