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HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
Stable Identifier
R-HSA-8863915
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
recycling endosome membrane
Synonyms
1C07_HUMAN, HLA-C
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Fusion of ERC and phagosome (Homo sapiens)
Class I MHC HC:B2M:Erp57 [recycling endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [recycling endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10321 HLA-C
Gene Names
HLA-C, HLAC
Chain
signal peptide:1-24, chain:25-366
Reference Genes
BioGPS Gene:3107 HLA-C
COSMIC (genes):HLA-C HLA-C
CTD Gene:3107 HLA-C
dbSNP Gene:3107 HLA-C
ENSEMBL:ENSG00000204525 HLA-C
HGNC:4933 HLA-C
KEGG:hsa:3107 HLA-C
Monarch:3107 HLA-C
NCBI Gene:3107 HLA-C
UCSC:P10321 HLA-C
Reference Transcript
RefSeq:NM_002117.5 HLA-C
Other Identifiers
11715316_x_at
17017126
17029003
216526_PM_x_at
216526_x_at
2900985
2900990
2901160
2901186
2901190
2901216
2901249
2901470
2901471
2901631
2948892
2948893
2948894
2948896
2948897
2948898
2948899
2948900
2948901
2948902
2948903
2948904
2948905
2948906
2948907
2948908
2948909
2948910
2948911
2948912
2948913
2948914
2948915
2948916
2948917
2948918
2948919
2948945
2948946
2948951
3107
8124901
8178489
A_24_P298409
A_33_P3330109
GO:0000139
GO:0001916
GO:0002250
GO:0002376
GO:0002474
GO:0002476
GO:0002486
GO:0005102
GO:0005515
GO:0005615
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0009897
GO:0009986
GO:0012507
GO:0016020
GO:0019882
GO:0030667
GO:0030670
GO:0031901
GO:0042605
GO:0042612
GO:0043226
GO:0045087
GO:0046977
GO:0055038
GO:0070062
GO:0098542
GO:0098553
HMNXSV003005502
HMNXSV003026726
Hs.277477.2.S1_3p_x_at
ILMN_1721113
ILMN_2150787
TC06004059.hg
TC6_cox_hap2000236.hg
Participates
as a member of
Class I MHC heavy chain (MHC HC) [recycling endosome membrane] (Homo sapiens)
Other forms of this molecule
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
Inferred To
RT1-M1-5 [recycling endosome membrane]
(Rattus norvegicus)
RT1-M2 [recycling endosome membrane]
(Rattus norvegicus)
mhc1zfa [recycling endosome membrane]
(Danio rerio)
RT1-M1-2 [recycling endosome membrane]
(Rattus norvegicus)
BF1 [recycling endosome membrane]
(Gallus gallus)
H2-T3 [recycling endosome membrane]
(Mus musculus)
H2-D1 [recycling endosome membrane]
(Mus musculus)
mhc1zca [recycling endosome membrane]
(Danio rerio)
H2-M2 [recycling endosome membrane]
(Mus musculus)
H2-M10.1 [recycling endosome membrane]
(Mus musculus)
RT1-M3-1 [recycling endosome membrane]
(Rattus norvegicus)
H2-Q10 [recycling endosome membrane]
(Mus musculus)
H2-M10.4 [recycling endosome membrane]
(Mus musculus)
H2-M5 [recycling endosome membrane]
(Mus musculus)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Bos taurus)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Canis familiaris)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Danio rerio)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Gallus gallus)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Mus musculus)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Rattus norvegicus)
Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Sus scrofa)
mhc1uba [recycling endosome membrane]
(Danio rerio)
RT1-M10-1 [recycling endosome membrane]
(Rattus norvegicus)
H2-T23 [recycling endosome membrane]
(Mus musculus)
RT1-O1l1 [recycling endosome membrane]
(Rattus norvegicus)
H2-Q7 [recycling endosome membrane]
(Mus musculus)
RT1-CE2 [recycling endosome membrane]
(Rattus norvegicus)
H2-Q4 [recycling endosome membrane]
(Mus musculus)
H2-Q1 [recycling endosome membrane]
(Mus musculus)
H2-M10.5 [recycling endosome membrane]
(Mus musculus)
RT1-S3 [recycling endosome membrane]
(Rattus norvegicus)
H2-M10.6l [recycling endosome membrane]
(Rattus norvegicus)
LOC100513601 [recycling endosome membrane]
(Sus scrofa)
ENSRNOG00000069480 [recycling endosome membrane]
(Rattus norvegicus)
mhc1uma [recycling endosome membrane]
(Danio rerio)
BFIV21 [recycling endosome membrane]
(Gallus gallus)
SLA-3 [recycling endosome membrane]
(Sus scrofa)
H2-M9 [recycling endosome membrane]
(Mus musculus)
RT1-M5 [recycling endosome membrane]
(Rattus norvegicus)
SLA-6 [recycling endosome membrane]
(Sus scrofa)
DLA88 [recycling endosome membrane]
(Canis familiaris)
mhc1zba [recycling endosome membrane]
(Danio rerio)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Bos taurus)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Canis familiaris)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Gallus gallus)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Mus musculus)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(Sus scrofa)
RT1-CE10 [recycling endosome membrane]
(Rattus norvegicus)
H2-M3 [recycling endosome membrane]
(Mus musculus)
AABR07044308.2 [recycling endosome membrane]
(Rattus norvegicus)
H2-K1 [recycling endosome membrane]
(Mus musculus)
H2-M10.2 [recycling endosome membrane]
(Mus musculus)
H2-T22 [recycling endosome membrane]
(Mus musculus)
RT1-M1-4 [recycling endosome membrane]
(Rattus norvegicus)
SLA-8 [recycling endosome membrane]
(Sus scrofa)
H2-Q2 [recycling endosome membrane]
(Mus musculus)
RT1-CE14 [recycling endosome membrane]
(Rattus norvegicus)
SLA-2 [recycling endosome membrane]
(Sus scrofa)
H2-M10.3 [recycling endosome membrane]
(Mus musculus)
H2-M11 [recycling endosome membrane]
(Mus musculus)
ENSRNOG00000064836 [recycling endosome membrane]
(Rattus norvegicus)
mhc1zda [recycling endosome membrane]
(Danio rerio)
DLA-12 [recycling endosome membrane]
(Canis familiaris)
H2-M10.6 [recycling endosome membrane]
(Mus musculus)
DLA-79 [recycling endosome membrane]
(Canis familiaris)
H2-M1 [recycling endosome membrane]
(Mus musculus)
RT1-CE16 [recycling endosome membrane]
(Rattus norvegicus)
LOC119876868 [recycling endosome membrane]
(Canis familiaris)
SLA-7 [recycling endosome membrane]
(Sus scrofa)
RT1-CE1 [recycling endosome membrane]
(Rattus norvegicus)
mhc1laa [recycling endosome membrane]
(Danio rerio)
mhc1zea [recycling endosome membrane]
(Danio rerio)
RT1-N3 [recycling endosome membrane]
(Rattus norvegicus)
AABR07044362.1 [recycling endosome membrane]
(Rattus norvegicus)
H2-Q6 [recycling endosome membrane]
(Mus musculus)
Cross References
RefSeq
NP_002108.4
ENSEMBL
ENST00000376228
,
ENSP00000365402
OpenTargets
ENSG00000204525
HPA
ENSG00000204525-HLA-C
PRO
P10321
Pharos - Targets
P10321
GlyGen
P10321
PDB
6JTO
,
5W6A
,
3BZF
,
4NT6
,
5VGD
,
5VGE
,
1IM9
,
1EFX
,
6PAG
,
5W67
,
6PA1
,
1QQD
,
5W69
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [plasma membrane]
(R-HSA-167743)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
0.875
11
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.792
15
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.643
3
UniProt:Q63HN8 RNF213
3
RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715284)
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715291)
RNF213 [cytosol]
(R-HSA-9635613)
0.564
2
UniProt:P01222 TSHB
1
TSHB [extracellular region]
(R-HSA-378957)
0.527
2
UniProt:Q01974 ROR2
2
ROR2 [plasma membrane]
(R-HSA-197731)
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
0.527
2
UniProt:A0PJW6 TMEM223
1
TMEM223 [mitochondrial inner membrane]
(R-HSA-9865797)
0.527
2
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