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p-11Y-PDGFRB [plasma membrane]
Stable Identifier
R-HSA-8864039
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-PDGFRB dephosphorylated at Y1021
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Homo sapiens)
p-11Y-PDGFRA:p-11Y-PDGFRB [plasma membrane] (Homo sapiens)
p-11Y-PDGFRB [plasma membrane] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
p-PDGFRB homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
p-11Y-PDGFRB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09619 PDGFRB
Gene Names
PDGFRB, PDGFR, PDGFR1
Chain
signal peptide:1-32, chain:33-1106
Reference Genes
BioGPS Gene:5159 PDGFRB
COSMIC (genes):PDGFRB PDGFRB
CTD Gene:5159 PDGFRB
dbSNP Gene:5159 PDGFRB
ENSEMBL:ENSG00000113721 PDGFRB
HGNC:8804 PDGFRB
KEGG:hsa:5159 PDGFRB
Monarch:5159 PDGFRB
NCBI Gene:5159 PDGFRB
OMIM:173410 PDGFRB
UCSC:P09619 PDGFRB
Reference Transcript
RefSeq:XM_011537658.1 PDGFRB
RefSeq:NM_002609.3 PDGFRB
RefSeq:XM_011537659.1 PDGFRB
Other Identifiers
11715852_at
11715853_a_at
11715854_at
17001578
1771_s_at
202273_PM_at
202273_at
2881238
2881242
2881243
2881244
2881245
2881246
2881247
2881248
2881249
2881250
2881251
2881252
2881253
2881254
2881255
2881256
2881258
2881259
2881260
2881261
2881262
2881263
2881264
2881265
2881266
2881267
2881268
2881269
2881270
2881273
2881274
2881275
2881276
2881277
2881278
2881279
2881280
2881281
2881282
2881283
2881284
2881285
2881286
2881287
2881291
2881292
2881294
36993_at
5159
74696_r_at
8115099
GE57480
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004992
GO:0005017
GO:0005019
GO:0005096
GO:0005102
GO:0005161
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005886
GO:0005925
GO:0006468
GO:0006935
GO:0007010
GO:0007165
GO:0007169
GO:0007186
GO:0008284
GO:0014911
GO:0016020
GO:0016324
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0030335
GO:0031401
GO:0031410
GO:0032516
GO:0032956
GO:0035441
GO:0035791
GO:0035793
GO:0035909
GO:0036120
GO:0038085
GO:0038091
GO:0043202
GO:0043226
GO:0043231
GO:0043235
GO:0043406
GO:0045840
GO:0045937
GO:0046777
GO:0048008
GO:0048407
GO:0048661
GO:0048856
GO:0048870
GO:0050850
GO:0050921
GO:0051897
GO:0055003
GO:0060089
GO:0060326
GO:0060981
GO:0061298
GO:0070374
GO:0071670
GO:0072262
GO:0072277
GO:0090280
GO:0098772
GO:0140096
GO:0160185
GO:2000379
GO:2000573
HMNXSV003010193
ILMN_1815057
J03278_at
PH_hs_0023673
TC05001933.hg
TC05003303.hg
g4505682_3p_at
g4505682_3p_x_at
p13450
p13451
p26300
Participates
as a component of
p-11Y-PDGFRA:p-11Y-PDGFRB [plasma membrane] (Homo sapiens)
p-PDGFRB homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-12Y-PDGFRB [plasma membrane]
PDGFRB [plasma membrane]
Inferred To
Ghost homologue of p-11Y-PDGFRB [plasma membrane]
(Danio rerio)
phospho-p-11Y-PDGFRB [plasma membrane]
(Bos taurus)
phospho-p-11Y-PDGFRB [plasma membrane]
(Caenorhabditis elegans)
phospho-p-11Y-PDGFRB [plasma membrane]
(Canis familiaris)
phospho-p-11Y-PDGFRB [plasma membrane]
(Drosophila melanogaster)
phospho-p-11Y-PDGFRB [plasma membrane]
(Gallus gallus)
phospho-p-11Y-PDGFRB [plasma membrane]
(Mus musculus)
phospho-p-11Y-PDGFRB [plasma membrane]
(Rattus norvegicus)
phospho-p-11Y-PDGFRB [plasma membrane]
(Sus scrofa)
phospho-p-11Y-PDGFRB [plasma membrane]
(Xenopus tropicalis)
phospho-kin-36 [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-11Y-PDGFRB [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1009
Coordinate
1009
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 579
Coordinate
579
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 581
Coordinate
581
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 716
Coordinate
716
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 740
Coordinate
740
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 751
Coordinate
751
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 763
Coordinate
763
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 775
Coordinate
775
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 778
Coordinate
778
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 857
Coordinate
857
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011535960.1
,
NP_002600.1
,
XP_011535961.1
ZINC - World Drugs
PGFRB_HUMAN
Guide to Pharmacology - Targets
1804
OpenTargets
ENSG00000113721
ENSEMBL
ENST00000261799
,
ENSP00000261799
ZINC - FDA approved
PGFRB_HUMAN
ZINC - Substances
PGFRB_HUMAN
ZINC - Biogenic
PGFRB_HUMAN
ZINC target
P09619
PRO
P09619
PDB
2PLE
,
2PLD
,
1SHA
,
1GQ5
,
2L6W
,
2IUI
,
3MJG
,
1H9O
ZINC - Investigational
PGFRB_HUMAN
ZINC - Metabolites
PGFRB_HUMAN
HPA
ENSG00000113721-PDGFRB
Pharos - Targets
P09619
Orphanet
PDGFRB
ZINC - Predictions - Purchasable
PGFRB_HUMAN
HMDB Protein
HMDBP01435
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.951
21
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.902
8
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.851
7
UniProt:P23727
3
PIK3R1 [cytosol]
(R-BTA-3080572)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [plasma membrane]
(R-BTA-198365)
0.725
6
UniProt:Q12913 PTPRJ
2
PTPRJ [specific granule membrane]
(R-HSA-6799570)
PTPRJ [plasma membrane]
(R-HSA-6785269)
0.715
4
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.713
3
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.706
5
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.704
3
UniProt:P60484 PTEN
20
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
0.675
3
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.643
3
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.643
3
UniProt:P41499 Ptpn11
5
p-Y-Shp2 [cytosol]
(R-RNO-1369098)
Ptpn11 [cytosol]
(R-RNO-548923)
PTPN11 [nucleoplasm]
(R-RNO-8937745)
PTPN11 [cytosol]
(R-RNO-162563)
phospho-p-Y542,Y580-PTPN11 [cytosol]
(R-RNO-162573)
0.59
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q13535 ATR
1
ATR [nucleoplasm]
(R-HSA-912443)
0.527
2
UniProt:P35918 Kdr
5
p-Y799,Y1052,Y1172-Kdr [plasma membrane]
(R-MMU-9860469)
Kdr [plasma membrane]
(R-MMU-9860502)
Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane]
(R-MMU-5218738)
VEGFR2 [plasma membrane]
(R-MMU-195382)
phospho-p-6Y-VEGFR2 [plasma membrane]
(R-MMU-4420103)
0.524
4
UniProt:P04085 PDGFA
1
PDGFA [extracellular region]
(R-HSA-2426265)
0.524
5
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.524
3
UniProt:Q13239 SLA
1
SLA [cytosol]
(R-HSA-9706158)
0.462
4
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.462
4
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.462
2
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