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EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
Stable Identifier
R-HSA-8864124
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10910043
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
Klapper, LN
,
Yarden, Y
,
Sela, M
,
Waterman, H
Cancer Res.
2000
Participants
components
EGF:p-6Y-EGFR [plasma membrane]
(Homo sapiens)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Homo sapiens)
Participates
as a member of
Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] (Homo sapiens)
Inferred To
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Caenorhabditis elegans)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Canis familiaris)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Drosophila melanogaster)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Gallus gallus)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Mus musculus)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Rattus norvegicus)
EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(Sus scrofa)
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