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Ub-C85-UBE2D2 [nucleoplasm]
Stable Identifier
R-HSA-8864153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 D2 ecNumber evidence="13 15 16 17"2.3.2.23/ecNumber, UB2D2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C85-UBE2D2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62837 UBE2D2
Gene Names
UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
Chain
chain:1-147
Reference Genes
BioGPS Gene:7322 UBE2D2
COSMIC (genes):UBE2D2 UBE2D2
CTD Gene:7322 UBE2D2
dbSNP Gene:7322 UBE2D2
ENSEMBL:ENSG00000131508 UBE2D2
HGNC:12475 UBE2D2
KEGG Gene (Homo sapiens):7322 UBE2D2
Monarch:7322 UBE2D2
NCBI Gene:7322 UBE2D2
OMIM:602962 UBE2D2
UCSC:P62837 UBE2D2
Reference Transcript
RefSeq:NM_003339.2 UBE2D2
RefSeq:NM_181838.1 UBE2D2
Other Identifiers
0002650458
0003440541
11722198_a_at
11756859_a_at
11757555_s_at
16989881
201343_at
201344_at
201345_s_at
2831285
2831290
2831291
2831292
2831294
2831297
2831299
2831301
2831303
2831304
2831307
2831308
2831309
2831310
2831311
38705_at
4038316
50909_at
7322
8108435
832_at
A_14_P107754
A_23_P305677
A_23_P58622
A_33_P3310674
GE61672
GO:0000151
GO:0000166
GO:0000209
GO:0002756
GO:0003674
GO:0004842
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0007165
GO:0008104
GO:0008150
GO:0009056
GO:0016567
GO:0016740
GO:0032991
GO:0035666
GO:0043167
GO:0043226
GO:0051865
GO:0061630
GO:0061631
GO:0070062
GO:0070936
HMNXSV003048923
Hs.108332.0.S2_3p_at
Hs.108332.0.S3_3p_at
ILMN_1677756
ILMN_1699503
ILMN_1725644
PH_hs_0006001
TC05000713.hg
TC05002650.hg
U39317_at
g4507774_3p_a_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-C85-UBE2D2 [cytosol]
UBE2D2 [nucleoplasm]
UBE2D2 [cytosol]
Inferred To
ubc4 [nucleoplasm]
(Schizosaccharomyces pombe)
UBE2D2 [nucleoplasm]
(Canis familiaris)
UBE2D2 [nucleoplasm]
(Sus scrofa)
Ube2d2 [nucleoplasm]
(Mus musculus)
Ube2d2 [nucleoplasm]
(Rattus norvegicus)
let-70 [nucleoplasm]
(Caenorhabditis elegans)
eff [nucleoplasm]
(Drosophila melanogaster)
UBC4 [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-C85-UBE2D2 [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003330.1
,
NP_862821.1
OpenTargets
ENSG00000131508
IntEnz
2.3.2.23
HPA
ENSG00000131508-UBE2D2
GeneCards
P62837
Ensembl
ENSG00000131508
,
ENST00000511725
,
ENSP00000429613
,
ENSP00000424941
,
ENST00000505548
,
ENSP00000381718
,
ENST00000398734
,
ENSP00000381717
,
ENST00000398733
PRO
P62837
Pharos - Targets
P62837
HMDB Protein
HMDBP00587
PDB
6SQS
,
5D1K
,
7AI1
,
6SQR
,
7AI0
,
2ESK
,
4A49
,
6HPR
,
5D1M
,
5ZBU
,
4WZ3
,
2ESO
,
5D1L
,
4LDT
,
2CLW
,
3L1Y
,
5ULK
,
6W7Z
,
3ZNI
,
3A33
,
5VZW
,
1UR6
,
6SQO
,
1W4U
,
6M2C
,
5ULF
,
5D0M
,
6TTU
,
5D0K
,
5EDV
,
4V3K
,
7BOL
,
3JVZ
,
4AUQ
,
5ULH
,
4V3L
,
2ESP
,
3TGD
,
2ESQ
,
4A4B
,
4A4C
,
5MNJ
,
4DDG
,
6W9D
,
4DDI
,
3JW0
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
0.708
5
UniProt:P22681 CBL
20
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
0.611
4
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.558
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.553
2
UniProt:Q6ZNA4 RNF111
2
RNF111 [nucleoplasm]
(R-HSA-2186765)
RNF111 [cytosol]
(R-HSA-975981)
0.553
2
UniProt:P98170 XIAP
3
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.527
2
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