Reactome | Ub-C85-UBE2D2 [nucleoplasm]

Ub-C85-UBE2D2 [nucleoplasm]

Stable Identifier

R-HSA-8864153

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 D2 ecNumber evidence="13 15 16 17"2.3.2.23/ecNumber, UB2D2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C85-UBE2D2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62837 UBE2D2

Gene Names

UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B

Chain

chain:1-147

Reference Genes

BioGPS Gene:7322 UBE2D2

COSMIC (genes):UBE2D2 UBE2D2

CTD Gene:7322 UBE2D2

dbSNP Gene:7322 UBE2D2

ENSEMBL:ENSG00000131508 UBE2D2

HGNC:12475 UBE2D2

KEGG Gene (Homo sapiens):7322 UBE2D2

Monarch:7322 UBE2D2

NCBI Gene:7322 UBE2D2

OMIM:602962 UBE2D2

UCSC:P62837 UBE2D2

Reference Transcript

Other Identifiers

0002650458

0003440541

11722198_a_at

11756859_a_at

11757555_s_at

16989881

201343_at

201344_at

201345_s_at

2831285

2831290

2831291

2831292

2831294

2831297

2831299

2831301

2831303

2831304

2831307

2831308

2831309

2831310

2831311

38705_at

4038316

50909_at

7322

8108435

832_at

A_14_P107754

A_23_P305677

A_23_P58622

A_33_P3310674

GE61672

GO:0000151

GO:0000166

GO:0000209

GO:0002756

GO:0003674

GO:0004842

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0007165

GO:0008104

GO:0008150

GO:0009056

GO:0016567

GO:0016740

GO:0032991

GO:0035666

GO:0043167

GO:0043226

GO:0051865

GO:0061630

GO:0061631

GO:0070062

GO:0070936

HMNXSV003048923

Hs.108332.0.S2_3p_at

Hs.108332.0.S3_3p_at

ILMN_1677756

ILMN_1699503

ILMN_1725644

PH_hs_0006001

TC05000713.hg

TC05002650.hg

U39317_at

g4507774_3p_a_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-C85-UBE2D2 [cytosol]

UBE2D2 [nucleoplasm]

UBE2D2 [cytosol]

Inferred To

ubc4 [nucleoplasm] (Schizosaccharomyces pombe)

UBE2D2 [nucleoplasm] (Canis familiaris)

UBE2D2 [nucleoplasm] (Sus scrofa)

Ube2d2 [nucleoplasm] (Mus musculus)

Ube2d2 [nucleoplasm] (Rattus norvegicus)

let-70 [nucleoplasm] (Caenorhabditis elegans)

eff [nucleoplasm] (Drosophila melanogaster)

UBC4 [nucleoplasm] (Saccharomyces cerevisiae)

Ub-C85-UBE2D2 [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 85

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_003330.1, NP_862821.1

OpenTargets

ENSG00000131508

IntEnz

2.3.2.23

GeneCards

P62837

HPA

ENSG00000131508-UBE2D2

Ensembl

ENST00000511725, ENSP00000424941, ENSP00000429613, ENST00000505548, ENSP00000381718, ENSP00000381717, ENST00000398734, ENST00000398733, ENSG00000131508

PRO

P62837

Pharos - Targets

P62837

HMDB Protein

HMDBP00587

PDB

5D0K, 1UR6, 6W9D, 4A49, 4V3L, 5D1M, 4LDT, 2ESQ, 6TTU, 5D0M, 6SQO, 4A4B, 2ESP, 4A4C, 5MNJ, 2ESO, 6W7Z, 4DDG, 6SQR, 3L1Y, 6HPR, 5EDV, 5ZBU, 4DDI, 2ESK, 5ULF, 3A33, 6SQS, 5D1K, 3ZNI, 4WZ3, 4AUQ, 5ULH, 3JVZ, 5D1L, 3JW0, 1W4U, 5VZW, 5ULK, 3TGD, 2CLW, 4V3K

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272)	0.708	5
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.611	4
UniProt:Q13616 CUL1	3	CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [cytosol] (R-HSA-174230)	0.558	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.553	2
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.527	2

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