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Ub-C85-UBE2D1 [cytosol]
Stable Identifier
R-HSA-8864160
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UbcH5/Ubc4
Icon
Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
Ub-C85-UBE2D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51668 UBE2D1
Gene Names
UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Chain
chain:1-147
Reference Genes
BioGPS Gene:7321 UBE2D1
COSMIC (genes):UBE2D1 UBE2D1
CTD Gene:7321 UBE2D1
dbSNP Gene:7321 UBE2D1
ENSEMBL:ENSG00000072401 UBE2D1
ENSEMBL_homo_sapiens_GENE:ENSG00000072401.15 UBE2D1
HGNC:12474 UBE2D1
KEGG Gene (Homo sapiens):7321 UBE2D1
Monarch:7321 UBE2D1
NCBI Gene:7321 UBE2D1
OMIM:602961 UBE2D1
UCSC:P51668 UBE2D1
Reference Transcript
RefSeq:NM_003338.4 UBE2D1
Other Identifiers
1164_at
11723042_at
11723043_at
16705064
211764_PM_s_at
211764_s_at
214590_PM_s_at
214590_s_at
3247758
3247764
3247765
3247766
3247768
3247769
3247771
3247772
3247773
3247774
3247775
37826_at
7321
7927658
A_24_P13032
A_24_P364025
GE79396
GO:0000122
GO:0000151
GO:0000166
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0016567
GO:0016740
GO:0019787
GO:0023052
GO:0030163
GO:0030514
GO:0031398
GO:0031625
GO:0032446
GO:0032991
GO:0036211
GO:0043161
GO:0043226
GO:0061630
GO:0061631
GO:0070936
GO:0140096
GO:1902916
GO:1904262
HMNXSV003032080
Hs.318435.0.S2_3p_s_at
ILMN_1787988
PH_hs_0007586
TC10000360.hg
g13543662_3p_s_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
as an output of
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
as a component of
Ub:UBE2D1 [cytosol] (Homo sapiens)
Other forms of this molecule
UBE2D1 [cytosol]
UBE2D1 [nucleoplasm]
Inferred To
UBE2D1 [cytosol]
(Bos taurus)
UBE2D1 [cytosol]
(Canis familiaris)
UBE2D1 [cytosol]
(Sus scrofa)
ubc14 [cytosol]
(Schizosaccharomyces pombe)
ubc4 [cytosol]
(Schizosaccharomyces pombe)
Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
Ub-C85-UBE2D1 [cytosol]
(Gallus gallus)
Ub-C85-UBE2D1 [cytosol]
(Plasmodium falciparum)
Ghost homologue of Ub-C85-UBE2D1 [cytosol]
(Xenopus tropicalis)
UBC5 [cytosol]
(Saccharomyces cerevisiae)
ube2d1b [cytosol]
(Danio rerio)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Schizosaccharomyces pombe)
eff [cytosol]
(Drosophila melanogaster)
Ube2d1 [cytosol]
(Mus musculus)
Ube2d1 [cytosol]
(Rattus norvegicus)
UBC4 [cytosol]
(Saccharomyces cerevisiae)
let-70 [cytosol]
(Caenorhabditis elegans)
ubcB [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003329.1
Guide to Pharmacology - Targets
3228
OpenTargets
ENSG00000072401
GeneCards
P51668
HPA
ENSG00000072401-UBE2D1
Ensembl
ENSP00000363019
,
ENST00000373910
,
ENSG00000072401
PRO
P51668
Pharos - Targets
P51668
HMDB Protein
HMDBP00572
PDB
3OJ4
,
7ZJ3
,
5FER
,
3PTF
,
4QPL
,
4AP4
,
2YHO
,
2C4P
,
6D4P
,
5TUT
Interactors (50)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.851
15
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.83
12
UniProt:Q9BV68 RNF126
1
RNF126 [cytosol]
(R-HSA-8851642)
0.817
7
UniProt:Q96BH1 RNF25
1
RNF25 [cytosol]
(R-HSA-975976)
0.801
6
UniProt:Q9HCM9 TRIM39
1
TRIM39 [cytosol]
(R-HSA-5688971)
0.8
6
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.795
10
UniProt:Q9Y3C5 RNF11
0.788
9
UniProt:Q8ND25 ZNRF1
1
ZNRF1 [cytosol]
(R-HSA-8850903)
0.788
9
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.782
6
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.781
7
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.781
7
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.742
5
UniProt:Q9UJV3-2 MID2
0.718
6
UniProt:Q9H000 MKRN2
0.718
6
UniProt:Q13064 MKRN3
0.666
4
UniProt:Q96GF1 RNF185
1
RNF185 [endoplasmic reticulum membrane]
(R-HSA-8861819)
0.666
4
UniProt:Q9P0P0 RNF181
1
RNF181 [cytoplasm]
(R-HSA-8939317)
0.666
4
UniProt:Q9UBS8 RNF14
1
RNF14 [cytosol]
(R-HSA-5688974)
0.666
4
UniProt:Q8N9I9 DTX3
0.666
6
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.666
4
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.666
6
UniProt:Q9BZR9 TRIM8
1
TRIM8 [cytosol]
(R-HSA-5624332)
0.666
4
IntAct:EBI-4399559 UBIQ
0.623
3
UniProt:Q8N5U6 RNF10
0.621
3
UniProt:Q9Y508 RNF114
1
RNF114 [cytosol]
(R-HSA-8850894)
0.621
3
UniProt:Q9CZW6
1
RNF146 [cytosol]
(R-MMU-3640827)
0.558
2
UniProt:P62990 UBIQ
0.558
2
UniProt:Q9HCM9-2 TRIM39
0.556
5
UniProt:O75382 TRIM3
1
TRIM3 [cytosol]
(R-HSA-5624344)
0.556
3
UniProt:Q96EP1-2 CHFR
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
3
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
IntAct:EBI-22462114 CCSB ORF ID
0.556
3
UniProt:Q9HAC8 UBTD1
0.556
3
UniProt:Q96B67 ARRD3
0.556
5
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.556
3
UniProt:Q9UHC7 MKRN1
2
MKRN1 [cytosol]
(R-HSA-976042)
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q86XT4 TRIM50
1
TRIM50 [cytosol]
(R-HSA-5688976)
0.556
5
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:Q6PCD5 RFWD3
0.553
2
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.553
2
UniProt:Q9NS56 TOPORS
2
monoSUMO1-K560-TOPORS [nucleoplasm]
(R-HSA-4551754)
TOPORS [nucleoplasm]
(R-HSA-2993791)
0.547
2
UniProt:O88846
1
RNF4 [cytosol]
(R-RNO-975974)
0.544
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.527
2
UniProt:Q96EP1 CHFR
0.488
2
UniProt:Q9NZS9 BFAR
0.488
2
UniProt:Q86Y13 DZIP3
1
DZIP3 [cytosol]
(R-HSA-976002)
0.488
2
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