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Ub-C85-UBE2D3 [cytosol]
Stable Identifier
R-HSA-8864191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UbcH5c, Ubiquitin-conjugating enzyme E2 D3, UB2D3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61077 UBE2D3
Gene Names
UBE2D3, UBC5C, UBCH5C
Chain
chain:1-147
Reference Genes
BioGPS Gene:7323 UBE2D3
COSMIC (genes):UBE2D3 UBE2D3
CTD Gene:7323 UBE2D3
dbSNP Gene:7323 UBE2D3
ENSEMBL:ENSG00000109332 UBE2D3
ENSEMBL_homo_sapiens_GENE:ENSG00000109332.20 UBE2D3
HGNC:12476 UBE2D3
KEGG Gene (Homo sapiens):7323 UBE2D3
Monarch:7323 UBE2D3
NCBI Gene:7323 UBE2D3
OMIM:602963 UBE2D3
UCSC:P61077 UBE2D3
Reference Transcript
RefSeq:NM_003340.6 UBE2D3
RefSeq:NM_181888.3 UBE2D3
RefSeq:NM_181890.2 UBE2D3
RefSeq:NM_181893.2 UBE2D3
RefSeq:NM_181892.3 UBE2D3
RefSeq:NM_181887.2 UBE2D3
RefSeq:NM_181886.3 UBE2D3
RefSeq:NM_181889.2 UBE2D3
RefSeq:NM_181891.2 UBE2D3
Other Identifiers
11719272_s_at
11719273_x_at
11722999_x_at
11742939_a_at
11742940_s_at
11742941_x_at
11742942_s_at
16978470
200667_PM_at
200667_at
200668_PM_s_at
200668_s_at
200669_PM_s_at
200669_s_at
229355_PM_at
229355_at
2779993
2779994
2779995
2779996
2779997
2779998
2779999
2780000
2780001
2780003
2780004
2780005
2780008
2780010
2780017
2780018
2780032
2780033
2780034
2780035
2780036
2780037
2780038
2780039
2780040
2780047
2780048
2780053
3896295
3896296
3896298
39083_at
504_at
50666_at
7323
75179_at
8102024
8180329
8180330
8180331
8180332
8180333
8180334
8180335
91086_at
A_23_P58293
A_24_P363005
A_24_P54847
GE79686
GE85983
GO:0000122
GO:0000151
GO:0000166
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005768
GO:0005829
GO:0005886
GO:0006281
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006886
GO:0006915
GO:0006974
GO:0007005
GO:0010008
GO:0012501
GO:0016020
GO:0016567
GO:0016740
GO:0019787
GO:0023052
GO:0030163
GO:0030514
GO:0031410
GO:0031625
GO:0032446
GO:0036211
GO:0043161
GO:0043226
GO:0051865
GO:0061630
GO:0061631
GO:0070062
GO:0070936
GO:0070979
GO:0085020
GO:0140096
GO:1903955
HMNXSV003015059
HMNXSV003054465
Hs.118797.0.A3_3p_at
Hs.118797.1.A1_3p_at
ILMN_2241679
ILMN_2292963
ILMN_2320850
ILMN_2320853
PH_hs_0024881
PH_hs_0033217
U39318_at
g13097281_3p_a_at
g4507776_3p_a_at
Participates
as a member of
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
as an output of
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)
as a component of
Ub:UBE2D3 [cytosol] (Homo sapiens)
Other forms of this molecule
UBE2D3 [nucleoplasm]
UBE2D3 [cytosol]
Inferred To
Ube2d3 [cytosol]
(Mus musculus)
Ube2d3 [cytosol]
(Rattus norvegicus)
UBE2D3 [cytosol]
(Bos taurus)
UBE2D3 [cytosol]
(Canis familiaris)
UBE2D3 [cytosol]
(Sus scrofa)
Ub-C85-UBE2D3 [cytosol]
(Gallus gallus)
Ghost homologue of Ub-C85-UBE2D3 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of Ub-C85-UBE2D3 [cytosol]
(Drosophila melanogaster)
Ghost homologue of Ub-C85-UBE2D3 [cytosol]
(Plasmodium falciparum)
Ghost homologue of Ub-C85-UBE2D3 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_871622.1
,
NP_871615.1
,
NP_871617.1
,
NP_871619.1
,
NP_871621.1
,
NP_871618.1
,
NP_871616.1
,
NP_003331.1
,
NP_871620.1
OpenTargets
ENSG00000109332
IntEnz
2.3.2.23
GeneCards
P61077
HPA
ENSG00000109332-UBE2D3
Ensembl
ENSP00000396901
,
ENSP00000345285
,
ENSP00000318494
,
ENSP00000349722
,
ENST00000394803
,
ENST00000357194
,
ENST00000394801
,
ENST00000343106
,
ENST00000394804
,
ENSP00000344069
,
ENST00000349311
,
ENSP00000378283
,
ENSP00000378282
,
ENST00000338145
,
ENSG00000109332
,
ENST00000321805
,
ENSP00000378280
,
ENST00000453744
,
ENSP00000337208
PRO
P61077
Pharos - Targets
P61077
HMDB Protein
HMDBP00610
PDB
3L1Z
,
7LYB
,
8SN4
,
6T7F
,
8SN6
,
4R8P
,
8UQC
,
8SN5
,
8UQD
,
8UPF
,
8SN2
,
8AMS
,
5EGG
,
8SN1
,
8SN3
,
8SNA
,
8UQA
,
3RPG
,
1X23
,
4S3O
,
8UQB
,
7JZV
,
8SN9
,
8SN0
,
8SMY
,
3UGB
,
4BVU
,
2FUH
,
8SMX
,
8U14
,
8SMZ
,
8UQ9
,
5IFR
,
8SMW
,
8SN7
,
8SN8
,
8UQ8
,
8UQE
,
8GRQ
,
6CP0
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.874
14
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.841
11
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.83
8
UniProt:Q96BH1 RNF25
1
RNF25 [cytosol]
(R-HSA-975976)
0.801
8
UniProt:Q9HCM9 TRIM39
1
TRIM39 [cytosol]
(R-HSA-5688971)
0.8
6
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.781
11
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.742
5
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.718
9
UniProt:Q9BV68 RNF126
1
RNF126 [cytosol]
(R-HSA-8851642)
0.712
4
UniProt:Q99PZ6 OSPG
0.669
6
UniProt:Q8N9I9 DTX3
0.666
4
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.666
6
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.658
3
UniProt:Q9Y3C5 RNF11
0.646
3
UniProt:Q8ND25 ZNRF1
1
ZNRF1 [cytosol]
(R-HSA-8850903)
0.621
3
UniProt:Q68DV7 RNF43
10
RNF43 E174* [plasma membrane]
(R-HSA-5340574)
RNF43 R330fs*89 [plasma membrane]
(R-HSA-5340581)
RNF43 A169T [plasma membrane]
(R-HSA-9666639)
RNF43 R117Afs*41 [plasma membrane]
(R-HSA-9666664)
RNF43 R132* [plasma membrane]
(R-HSA-9666650)
RNF43 P154L [plasma membrane]
(R-HSA-9666646)
RNF43 F69C [plasma membrane]
(R-HSA-5340578)
RNF43 [plasma membrane]
(R-HSA-5323531)
ub-RNF43 [plasma membrane]
(R-HSA-5323547)
RNF43 G659Vfs*41 [plasma membrane]
(R-HSA-9666643)
0.592
2
IntAct:EBI-22462114 CCSB ORF ID
0.556
5
UniProt:Q9HAC8 UBTD1
0.556
6
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:Q9HCM9-2 TRIM39
0.556
5
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:Q6PCD5 RFWD3
0.553
2
UniProt:Q9BY78 RNF26
0.553
2
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.553
2
UniProt:Q6ZN04 MEX3B
0.553
2
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.553
2
UniProt:Q8N5U6 RNF10
0.547
2
UniProt:P0CE12 SSPH2
0.544
7
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.527
2
UniProt:Q9NZS9 BFAR
0.488
2
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