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Ub-C93-CDC34 [nucleoplasm]
Stable Identifier
R-HSA-8864204
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 R1 ecNumber evidence="14 19 24 25"2.3.2.23/ecNumber, UB2R1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C93-CDC34 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49427 CDC34
Gene Names
CDC34, UBCH3, UBE2R1
Chain
chain:1-236
Reference Genes
BioGPS Gene:997 CDC34
COSMIC (genes):CDC34 CDC34
CTD Gene:997 CDC34
dbSNP Gene:997 CDC34
ENSEMBL:ENSG00000099804 CDC34
ENSEMBL_homo_sapiens_GENE:ENSG00000099804.9 CDC34
HGNC:1734 CDC34
KEGG Gene (Homo sapiens):997 CDC34
Monarch:997 CDC34
NCBI Gene:997 CDC34
OMIM:116948 CDC34
UCSC:P49427 CDC34
Reference Transcript
RefSeq:NM_004359.1 CDC34
Other Identifiers
11716983_at
11758296_s_at
1273_r_at
1274_s_at
16856187
212540_PM_at
212540_at
3814979
3814980
3814981
3814982
3814984
3814988
3814994
3814995
3814996
8023968
997
A_24_P177025
GE57676
GO:0000082
GO:0000166
GO:0000209
GO:0000278
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006260
GO:0006270
GO:0006511
GO:0007049
GO:0012501
GO:0016567
GO:0016607
GO:0016740
GO:0019787
GO:0023052
GO:0030163
GO:0032446
GO:0035458
GO:0036211
GO:0043161
GO:0043226
GO:0043525
GO:0043951
GO:0061631
GO:0070848
GO:0070936
GO:0090261
GO:0140096
HMNXSV003018337
HMNXSV003048812
Hs.76932.0.S1_3p_at
Hs.76932.0.S1_3p_x_at
ILMN_1713006
L22005_at
PH_hs_0019786
TC19000007.hg
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-C93-CDC34 [cytosol]
CDC34 [nucleoplasm]
CDC34 [cytosol]
Inferred To
cdc34 [nucleoplasm]
(Xenopus tropicalis)
CDC34 [nucleoplasm]
(Bos taurus)
CDC34 [nucleoplasm]
(Canis familiaris)
CDC34 [nucleoplasm]
(Gallus gallus)
CDC34 [nucleoplasm]
(Saccharomyces cerevisiae)
CDC34 [nucleoplasm]
(Sus scrofa)
ubc-3 [nucleoplasm]
(Caenorhabditis elegans)
cdc34b [nucleoplasm]
(Danio rerio)
Ub-C93-CDC34 [nucleoplasm]
(Dictyostelium discoideum)
Ub-C93-CDC34 [nucleoplasm]
(Plasmodium falciparum)
Homologues of Ub-C93-CDC34 [nucleoplasm]
(Danio rerio)
Homologues of Ub-C93-CDC34 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-C93-CDC34 [nucleoplasm]
(Plasmodium falciparum)
ubc15 [nucleoplasm]
(Schizosaccharomyces pombe)
Cdc34 [nucleoplasm]
(Mus musculus)
Cdc34 [nucleoplasm]
(Rattus norvegicus)
cdc34a [nucleoplasm]
(Danio rerio)
ubcC [nucleoplasm]
(Dictyostelium discoideum)
Dmel\CG7656 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 93
Coordinate
93
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_004350.1
OpenTargets
ENSG00000099804
IntEnz
2.3.2.24
HPA
ENSG00000099804-CDC34
GeneCards
P49427
Ensembl
ENSP00000215574
,
ENST00000215574
,
ENSG00000099804
PRO
P49427
Pharos - Targets
P49427
HMDB Protein
HMDBP11991
PDB
2OB4
,
8RX0
,
3RZ3
,
4MDK
,
7M2K
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.734
6
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
3
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.544
3
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