Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Ub-C86-UBE2L3 [nucleoplasm]
Stable Identifier
R-HSA-8864226
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 L3 ecNumber evidence="18"2.3.2.23/ecNumber, UB2L3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C86-UBE2L3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68036 UBE2L3
Gene Names
UBE2L3, UBCE7, UBCH7
Chain
chain:1-154
Reference Genes
BioGPS Gene:7332 UBE2L3
COSMIC (genes):UBE2L3 UBE2L3
CTD Gene:7332 UBE2L3
dbSNP Gene:7332 UBE2L3
ENSEMBL:ENSG00000185651 UBE2L3
HGNC:12488 UBE2L3
KEGG Gene (Homo sapiens):7332 UBE2L3
Monarch:7332 UBE2L3
NCBI Gene:7332 UBE2L3
OMIM:603721 UBE2L3
UCSC:P68036 UBE2L3
Reference Transcript
RefSeq:NM_001256356.1 UBE2L3
RefSeq:NM_003347.3 UBE2L3
RefSeq:NM_001256355.1 UBE2L3
Other Identifiers
0001740670
11718509_s_at
11718510_a_at
11718511_s_at
11749192_s_at
11749193_x_at
11754929_s_at
16927615
200676_s_at
200682_s_at
200683_s_at
200684_s_at
223_at
3483952
3483953
3536774
3536775
3536776
3536777
3820148
38701_at
3938176
3938177
3938183
3938188
3938197
3938198
3938199
3938200
3938201
3938202
3938203
3938204
3938205
3938206
3938207
64361_s_at
7332
7968331
8071547
A_21_P0000566
A_23_P166353
GE55131
GO:0000151
GO:0000166
GO:0000209
GO:0003674
GO:0003713
GO:0003723
GO:0004842
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006464
GO:0006511
GO:0006605
GO:0006810
GO:0007005
GO:0007049
GO:0008150
GO:0008283
GO:0009056
GO:0009058
GO:0015031
GO:0016567
GO:0016740
GO:0019899
GO:0030234
GO:0031398
GO:0031625
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0044770
GO:0045893
GO:0051443
GO:0061631
GO:0070979
GO:0071383
GO:0071385
GO:0097027
GO:1903955
HMNXSV003027099
Hs.108104.0.S1_3p_a_at
Hs.108104.0.S2_3p_a_at
Hs.108104.0.S3_3p_a_at
ILMN_1677877
PH_hs_0029083
S81003_at
TC22000092.hg
TC22000993.hg
g4507788_3p_x_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
UBE2L3 [nucleoplasm]
Ub-C86-UBE2L3 [cytosol]
UBE2L3 [cytosol]
Inferred To
Ube2l3 [nucleoplasm]
(Mus musculus)
ubc4 [nucleoplasm]
(Schizosaccharomyces pombe)
UBE2L3 [nucleoplasm]
(Canis familiaris)
UBE2L3 [nucleoplasm]
(Gallus gallus)
UBE2L3 [nucleoplasm]
(Sus scrofa)
Ub-C86-UBE2L3 [nucleoplasm]
(Dictyostelium discoideum)
ubc-18 [nucleoplasm]
(Caenorhabditis elegans)
ubc14 [nucleoplasm]
(Schizosaccharomyces pombe)
ube2l3a [nucleoplasm]
(Danio rerio)
UBC5 [nucleoplasm]
(Saccharomyces cerevisiae)
Ubc10 [nucleoplasm]
(Drosophila melanogaster)
ubcB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-C86-UBE2L3 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-C86-UBE2L3 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ub-C86-UBE2L3 [nucleoplasm]
(Schizosaccharomyces pombe)
UBC4 [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 86
Coordinate
86
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_001243284.1
,
NP_001243285.1
,
NP_003338.1
OpenTargets
ENSG00000185651
IntEnz
2.3.2.23
GeneCards
P68036
HPA
ENSG00000185651-UBE2L3
Ensembl
ENSP00000445931
,
ENST00000545681
,
ENSG00000185651
,
ENST00000342192
,
ENSP00000344259
,
ENST00000458578
,
ENSP00000400906
PRO
P68036
Pharos - Targets
P68036
GlyGen
P68036
Orphanet
22424
HMDB Protein
HMDBP00601
PDB
6XXU
,
5TTE
,
3SY2
,
6N13
,
5UDH
,
6DJX
,
1C4Z
,
4Q5H
,
4Q5E
,
6DJW
,
7B5N
,
1FBV
,
7B5L
,
3SQV
,
6CP2
,
5HPT
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95376 ARIH2
1
ARIH2 [cytosol]
(R-HSA-975987)
0.847
11
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.666
4
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.666
4
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.666
4
UniProt:Q99PZ6 OSPG
0.558
3
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:O60260-5 PRKN
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
3
UniProt:Q9NWF9 RNF216
1
RNF216 [cytosol]
(R-HSA-936043)
0.556
3
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
6
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.524
2
UniProt:Q96EQ8 RNF125
2
RNF125 [cytosol]
(R-HSA-918184)
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
0.488
2
UniProt:Q9NPC3 CIP1
0.482
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text