Reactome | TFAP2A [nucleoplasm]

TFAP2A [nucleoplasm]

Stable Identifier

R-HSA-8864280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor AP-2-alpha, AP2-alpha, AP-2, AP2TF, Activator protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P05549 TFAP2A

Gene Names

TFAP2A, AP2TF, TFAP2

Chain

chain:1-437

Reference Genes

BioGPS Gene:7020 TFAP2A

COSMIC (genes):TFAP2A TFAP2A

CTD Gene:7020 TFAP2A

dbSNP Gene:7020 TFAP2A

ENSEMBL:ENSG00000137203 TFAP2A

ENSEMBL:ENSG00000137203.15 TFAP2A

HGNC:11742 TFAP2A

KEGG Gene (Homo sapiens):7020 TFAP2A

Monarch:7020 TFAP2A

NCBI Gene:7020 TFAP2A

OMIM:107580 TFAP2A

UCSC:P05549 TFAP2A

Reference Transcript

Other Identifiers

11740388_a_at

11743641_x_at

11743642_s_at

11749049_a_at

11753337_a_at

204653_PM_at

204653_at

204654_PM_s_at

204654_s_at

2941482

2941483

2941484

2941485

2941486

2941487

2941488

2941489

2941490

2941495

2941496

2941499

2941502

2941503

2941504

2941509

2941510

2941511

2941512

2941513

2941514

2941525

2941526

2941527

32154_at

7020

792_s_at

8123864

A_32_P14187

A_33_P3361546

GE81248

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001822

GO:0003404

GO:0003409

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0007605

GO:0008285

GO:0010628

GO:0010842

GO:0010944

GO:0012501

GO:0021559

GO:0021623

GO:0030154

GO:0030501

GO:0035115

GO:0042127

GO:0042472

GO:0042802

GO:0043066

GO:0043226

GO:0043525

GO:0043565

GO:0045595

GO:0045892

GO:0045893

GO:0045944

GO:0048701

GO:0048856

GO:0050877

GO:0060021

GO:0060349

GO:0061029

GO:0070172

GO:0071281

GO:0140110

GO:0140536

GO:1990837

GO:2000378

HMNXSV003018887

Hs.18387.0.S2_3p_at

ILMN_1765574

ILMN_2275760

ILMN_2374115

PH_hs_0023068

TC06001260.hg

X52611_s_at

g4507440_3p_a_at

Participates

as a member of

as a component of

TFAP2A homodimer [nucleoplasm] (Homo sapiens)

Inferred To

aptf-2 [nucleoplasm] (Caenorhabditis elegans)

tfap2a [nucleoplasm] (Xenopus tropicalis)

aptf-1 [nucleoplasm] (Caenorhabditis elegans)

TfAP-2 [nucleoplasm] (Drosophila melanogaster)

Tfap2a [nucleoplasm] (Mus musculus)

Tfap2a [nucleoplasm] (Rattus norvegicus)

ap2 [nucleoplasm] (Danio rerio)

TFAP2A [nucleoplasm] (Bos taurus)

TFAP2A [nucleoplasm] (Canis familiaris)

TFAP2A [nucleoplasm] (Gallus gallus)

TFAP2A [nucleoplasm] (Sus scrofa)

aptf-4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of TFAP2A [nucleoplasm] (Caenorhabditis elegans)

aptf-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001027451.1, NP_001035890.1, NP_003211.1

OpenTargets

ENSG00000137203

GeneCards

P05549

HPA

ENSG00000137203-TFAP2A

Ensembl

ENSG00000137203, ENST00000319516, ENSP00000368928, ENST00000379608, ENSP00000316516

PRO

P05549

Pharos - Targets

P05549

Orphanet

17423

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.646	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.591	6
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.508	7

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