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TGOLN2 [plasma membrane]
Stable Identifier
R-HSA-8864458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Trans-Golgi network integral membrane protein 2, TGON2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
AP-2 directly binds some endocytic cargo (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
TGOLN2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43493 TGOLN2
Gene Names
TGOLN2, TGN46, TGN51
Chain
signal peptide:1-21, chain:22-437
Reference Genes
BioGPS Gene:10618 TGOLN2
COSMIC (genes):TGOLN2 TGOLN2
CTD Gene:10618 TGOLN2
dbSNP Gene:10618 TGOLN2
ENSEMBL:ENSG00000152291 TGOLN2
ENSEMBL_homo_sapiens_GENE:ENSG00000152291.15 TGOLN2
ENSEMBL_homo_sapiens_GENE:ENSG00000292253.1 TGOLN2
HGNC:15450 TGOLN2
KEGG Gene (Homo sapiens):10618 TGOLN2
Monarch:10618 TGOLN2
NCBI Gene:10618 TGOLN2
OMIM:603062 TGOLN2
UCSC:O43493 TGOLN2
Reference Transcript
RefSeq:NM_006464.3 TGOLN2
RefSeq:NM_001206840.1 TGOLN2
RefSeq:NM_001206841.1 TGOLN2
RefSeq:NM_001206844.1 TGOLN2
Other Identifiers
10618
11716901_s_at
11716902_a_at
11716903_a_at
11716904_s_at
11755687_x_at
1566473_3p_a_at
1566473_PM_a_at
1566473_a_at
16899619
203833_PM_s_at
203833_s_at
203834_PM_s_at
203834_s_at
212040_3p_at
212040_PM_at
212040_at
212043_PM_at
212043_at
2491521
2562200
2562201
2562202
2562203
2562204
2562205
2562209
2562210
2562211
2562212
2562213
2562214
2562215
2562216
2562217
2562218
2562220
2562221
2562222
2562224
2562226
2562228
2562230
31827_s_at
31828_r_at
31829_r_at
38993_r_at
8053388
A_23_P209933
A_24_P413988
GE81643
GE86506
GO:0005515
GO:0005634
GO:0005654
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0016020
GO:0030133
GO:0030140
GO:0030669
GO:0031410
GO:0043226
HMNXSV003044783
Hs.110771.0.S1_3p_x_at
Hs.110771.0.S2_3p_at
Hs.14894.0.S1_3p_a_at
Hs.14894.0.S1_3p_s_at
ILMN_1651735
PH_hs_0001402
PH_hs_0040170
TC02002035.hg
X94333_at
g5454115_3p_a_at
Participates
as a member of
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
Other forms of this molecule
TGOLN2 [clathrin-coated endocytic vesicle membrane]
TGOLN2 [Golgi membrane]
TGOLN2 [cytoplasmic vesicle membrane]
TGOLN2 [trans-Golgi network membrane]
TGOLN2 [transport vesicle]
p-TGOLN2 [endoplasmic reticulum lumen]
TGOLN2 [endoplasmic reticulum lumen]
Inferred To
Tgoln1 [plasma membrane]
(Mus musculus)
TGOLN2 [plasma membrane]
(Bos taurus)
TGOLN2 [plasma membrane]
(Canis familiaris)
TGOLN2 [plasma membrane]
(Gallus gallus)
TGOLN2 [plasma membrane]
(Sus scrofa)
Ttgn1 [plasma membrane]
(Rattus norvegicus)
rgn [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001193769.1
,
NP_001193770.1
,
NP_001193773.1
,
NP_006455.2
OpenTargets
ENSG00000152291
HPA
ENSG00000152291-TGOLN2
GeneCards
O43493
Ensembl
ENST00000377386
,
ENST00000398263
,
ENSP00000391190
,
ENSG00000152291
,
ENST00000409015
,
ENSP00000381312
,
ENST00000444342
,
ENSP00000387035
,
ENSP00000366603
PRO
O43493
Pharos - Targets
O43493
PDB
6YAF
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3P7 ACBD3
1
ACBD3 [Golgi membrane]
(R-HSA-8874981)
0.548
5
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.536
2
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