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Ub-C871-ITCH [cytosol]
Stable Identifier
R-HSA-8864515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase Itchy homolog, ITCH_HUMAN
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
ITCH polyubiquitinates MLKL at K50 (Homo sapiens)
Ub-C871-ITCH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96J02 ITCH
Gene Names
ITCH
Chain
initiator methionine:, chain:2-903
Reference Genes
COSMIC (genes):ITCH ITCH
dbSNP Gene:83737 ITCH
ENSEMBL:ENSG00000078747 ITCH
Other forms of this molecule
ITCH [cytosol]
Inferred To
ITCH [cytosol]
(Bos taurus)
Ub-C871-ITCH [cytosol]
(Sus scrofa)
Itch [cytosol]
(Mus musculus)
Itch [cytosol]
(Rattus norvegicus)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 871
Coordinate
871
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B67 ARRD3
0.768
5
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.75
5
UniProt:Q8N5I2 ARRD1
0.738
5
UniProt:Q9NW97 TMM51
0.688
4
UniProt:Q15884 EREP1
0.659
4
UniProt:Q96BR1 SGK3
1
SGK3 [cytosol]
(R-HSA-2682351)
0.645
5
UniProt:Q8N0X7 SPART
0.643
3
UniProt:O15350-1 TP73
0.639
5
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.623
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
15
UniProt:Q9ULV8 CBLC
0.602
5
UniProt:P08151 GLI1
9
ub-GLI1 [cytosol]
(R-HSA-5635833)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary base]
(R-HSA-5610357)
GLI1 [ciliary tip]
(R-HSA-5610360)
0.602
4
UniProt:O75113 N4BP1
3
N4BP1(1-490) [cytosol]
(R-HSA-9757922)
N4BP1(1-424) [cytosol]
(R-HSA-9757940)
N4BP1 [cytosol]
(R-HSA-9757941)
0.591
3
UniProt:P13285 LMP2
0.59
3
UniProt:Q16655 MLANA
1
MLANA [melanosome membrane]
(R-HSA-9825829)
0.59
2
UniProt:Q14511 CASL
0.581
3
UniProt:Q9BTU6 PI4K2A
1
PI4K2A [cytosol]
(R-HSA-1604617)
0.571
5
UniProt:Q96BY9 SARAF
0.564
2
UniProt:Q9Y3C5 RNF11
0.544
2
UniProt:Q8NCT1 ARRD4
0.527
2
UniProt:Q6UXU6 TMM92
0.527
2
UniProt:Q9H0M0 WWP1
1
WWP1 [cytosol]
(R-HSA-976037)
0.527
2
UniProt:Q5JRV8 T255A
0.527
2
UniProt:Q96G27 WBP1
0.527
2
UniProt:Q8WVE6 TM171
0.527
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.527
2
UniProt:Q99962 SH3GL2
4
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.526
3
UniProt:Q9QZS3-2 NUMB
0.524
2
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.499
2
UniProt:P70444
4
Bid [mitochondrial outer membrane]
(R-MMU-114266)
Bid [cytosol]
(R-MMU-141373)
Bid [cytosol]
(R-MMU-50825)
Bid [cytosol]
(R-MMU-139953)
0.471
2
UniProt:Q86Y01 DTX1
1
DTX1 [cytosol]
(R-HSA-1604437)
0.463
2
UniProt:Q9EPK8 Trpv4
1
Trpv4 [plasma membrane]
(R-MMU-9858833)
0.463
2
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