Reactome | PITX2 [nucleoplasm]

PITX2 [nucleoplasm]

Stable Identifier

R-HSA-8864726

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pituitary homeobox 2, ALL1-responsive protein ARP1, RIEG bicoid-related homeobox transcription factor, Solurshin, ARP1, RGS, RIEG, RIEG1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99697 PITX2

Gene Names

PITX2, ARP1, RGS, RIEG, RIEG1

Chain

chain:1-317

Reference Genes

BioGPS Gene:5308 PITX2

COSMIC (genes):PITX2 PITX2

CTD Gene:5308 PITX2

dbSNP Gene:5308 PITX2

ENSEMBL:ENSG00000164093 PITX2

HGNC:9005 PITX2

KEGG:hsa:5308 PITX2

Monarch:5308 PITX2

NCBI Gene:5308 PITX2

OMIM:601542 PITX2

UCSC:Q99697 PITX2

Reference Transcript

Participates

as an output of

PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)

Cross References

ENSEMBL

ENST00000355080, ENSP00000495061, ENST00000394595, ENSP00000378095, ENST00000354925, ENSG00000164093, ENSP00000347192, ENST00000644743, ENSP00000347004

OpenTargets

ENSG00000164093

GeneCards

PITX2

HPA

ENSG00000164093-PITX2

PRO

Q99697

Pharos - Targets

Q99697

Orphanet

PITX2

PDB

2L7M, 2L7F, 2LKX

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.499	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.483	2

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