SETD6 methylates RELA in the NFkB complex

Stable Identifier
R-HSA-8865237
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SET domain containing 6 (SETD6) is an N-lysine methyltransferase that monomethylates the RelA subunit of nuclear factor kappa B (NF-kB) at Lys-310 (Levy et al. 2011, Chang et al. 2011).
Literature References
PubMed ID Title Journal Year
21131967 Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

Tangsombatvisit, S, Tarakhovsky, A, Garcia, BA, Lee, K, Tanjing, S, Zee, BM, Kitson, C, Kuo, AY, Bedford, MT, Cheung, R, Cheng, X, Gozani, O, Cheung, P, Shi, X, Levy, D, Chua, KF, Kuo, AJ, Chang, Y, Prinjha, RK, Liu, CL, Schaefer, U, Utz, PJ, Tennen, RI, Espejo, A

Nat. Immunol. 2011
Participants
Participates
Catalyst Activity

protein-lysine N-methyltransferase activity of SETD6 [nucleoplasm]

Orthologous Events
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