TFAP2C homodimer binds the CDKN1A (p21) gene promoter

Stable Identifier
R-HSA-8865280
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TFAP2C homodimer binds the CDKN1A (p21) gene promoter
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TFAP2C (AP-2 gamma) transcription factor, in cooperation with MYC and histone demethylase KDM5B binds the proximal AP-2 response element in the promoter of the CDKN1A (p21) gene (Williams et al. 2009, Scibetta et al. 2010, Wong et al. 2012).
Literature References
PubMed ID Title Journal Year
22371483 Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)

Berlato, C, Hurst, HC, Miranda, F, Wong, PP, Scibetta, AG, Chan, KV

Mol. Cell. Biol. 2012
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Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-21)
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