Reactome | CBFB [nucleoplasm]

CBFB [nucleoplasm]

Stable Identifier

R-HSA-8865293

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Core-binding factor subunit beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, PEBB_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P12504 VIF

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External Reference Information

External Reference

UniProt:Q13951 CBFB

Gene Names

CBFB

Chain

chain:1-182

Reference Genes

BioGPS Gene:865 CBFB

COSMIC (genes):CBFB CBFB

CTD Gene:865 CBFB

dbSNP Gene:865 CBFB

ENSEMBL:ENSG00000067955 CBFB

HGNC:1539 CBFB

KEGG:hsa:865 CBFB

Monarch:865 CBFB

NCBI Gene:865 CBFB

OMIM:121360 CBFB

UCSC:Q13951 CBFB

Reference Transcript

Other Identifiers

11719017_a_at

11719018_at

11719019_at

16819952

202370_PM_s_at

202370_s_at

206788_PM_s_at

206788_s_at

3057035

3203077

3665088

3665117

3665118

3665120

3665121

3665122

3665123

3665124

3665125

3665126

3665127

3665128

3665129

3665130

3665131

3665132

3665133

3665134

3665154

41175_at

7996393

865

A_23_P113634

A_24_P107918

A_32_P111266

GE57663

GE84550

GO:0000122

GO:0000209

GO:0001503

GO:0001649

GO:0002376

GO:0003677

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0016020

GO:0016513

GO:0030098

GO:0030099

GO:0030154

GO:0043371

GO:0043378

GO:0043565

GO:0045893

GO:0045944

GO:0048469

GO:0048856

GO:0060216

HMNXSV003037269

ILMN_1766408

ILMN_2399489

L20298_at

PH_hs_0010651

TC16000528.hg

g13124872_3p_a_at

g9885832_3p_a_at

Participates

as a component of

as an input of

Inferred To

Cbfb [nucleoplasm] (Mus musculus)

Cbfb [nucleoplasm] (Rattus norvegicus)

bro-1 [nucleoplasm] (Caenorhabditis elegans)

cbfb [nucleoplasm] (Danio rerio)

cbfb [nucleoplasm] (Xenopus tropicalis)

CBFB [nucleoplasm] (Bos taurus)

CBFB [nucleoplasm] (Canis familiaris)

CBFB [nucleoplasm] (Gallus gallus)

CBFB [nucleoplasm] (Sus scrofa)

Bgb [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_074036.1, NP_001746.1

OpenTargets

ENSG00000067955

ENSEMBL

ENSP00000290858, ENST00000412916, ENSG00000067955, ENST00000290858, ENSP00000415151

HPA

ENSG00000067955-CBFB

GeneCards

CBFB

PRO

Q13951

Pharos - Targets

Q13951

Orphanet

CBFB

GlyGen

Q13951

PDB

6NIL, 8CX1, 1CL3, 8E40, 6VGD, 4N9F, 8J62, 8CX2, 8SZK, 1E50, 8FVI, 8CX0, 8H0I, 6VGG, 8FVJ, 6P59, 6VGE, 1H9D

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01196 RUNX1	5	RUNX1 [nucleoplasm] (R-HSA-8865295) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-S249,T273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) RUNX1 [plasma membrane] (R-HSA-5667138)	0.872	7
UniProt:P12504 VIF			0.691	10
UniProt:Q13950 RUNX2			0.669	4
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.612	5
UniProt:Q01196-8 RUNX1			0.556	3
UniProt:Q13761-2 RUNX3			0.556	3
UniProt:Q9NVM9 INTS13	1	ASUN [nucleoplasm] (R-HSA-6807447)	0.524	2
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.499	3
UniProt:Q15369-1 ELOC			0.462	2

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