BRWD1 binds SMARCA4

Stable Identifier
R-HSA-8865605
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BRWD1 binds SMARCA4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
BRWD1 (WDR9) is a nuclear protein with eight WD repeats at the N-terminus and 2 centrally located bromodomains. BRWD1 is thought to be involved in chromatin remodelling and transcriptional regulation. BRWD1 binds to Transcription activator BRG1 (SMARCA4 or BRG1), a component of the SWI/SNF complex(Huang et al. 2003). Similar to BRWD1 (Mandal et al. 2015), SMARCA4 is also implicated in B-cell development (Choi et al. 2012, Bossen et al. 2015).
Literature References
PubMed ID Title Journal Year
12889071 Expression of the Wdr9 gene and protein products during mouse development

Featherstone, M, Daniels, E, Rambaldi, I, Huang, H

Dev. Dyn. 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
BRWD1 binds SMARCA4 (Bos taurus)
BRWD1 binds SMARCA4 (Canis familiaris)
BRWD1 binds SMARCA4 (Dictyostelium discoideum)
BRWD1 binds SMARCA4 (Drosophila melanogaster)
BRWD1 binds SMARCA4 (Gallus gallus)
BRWD1 binds SMARCA4 (Mus musculus)
BRWD1 binds SMARCA4 (Rattus norvegicus)
BRWD1 binds SMARCA4 (Sus scrofa)
BRWD1 binds SMARCA4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-03-23)
Reviewed
Mandal, M  (2016-05-11)
Created
Orlic-Milacic, M  (2016-03-23)
Cite Us!