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CHERP [nucleoplasm]
Stable Identifier
R-HSA-8865901
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Calcium homeostasis endoplasmic reticulum protein, CHERP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
CHERP [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23148228
Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling
Hewitt, JE
,
Lin-Moshier, Y
,
Sampson, ND
,
Marchant, JS
,
Sebastian, PJ
,
Higgins, L
J. Biol. Chem.
2013
External Reference Information
External Reference
UniProt:Q8IWX8 CHERP
Gene Names
CHERP, DAN26, SCAF6
Chain
chain:1-916
Reference Genes
BioGPS Gene:10523 CHERP
COSMIC (genes):CHERP CHERP
CTD Gene:10523 CHERP
dbSNP Gene:10523 CHERP
ENSEMBL:ENSG00000085872 CHERP
HGNC:16930 CHERP
KEGG:hsa:10523 CHERP
Monarch:10523 CHERP
NCBI Gene:10523 CHERP
OMIM:618539 CHERP
UCSC:Q8IWX8 CHERP
Reference Transcript
RefSeq:NM_006387.5 CHERP
Other Identifiers
10523
11716769_x_at
11716770_at
11747199_a_at
1568704_3p_a_at
1568704_PM_a_at
1568704_a_at
16870023
202229_PM_s_at
202229_s_at
202230_PM_s_at
202230_s_at
3853941
3853943
3853944
3853945
3853946
3853947
3853948
3853949
3853950
3853951
3853952
3853953
3853954
3853955
3853956
3853958
3853961
3853963
3853964
3853967
3853968
3853969
3853970
3853971
3853975
3853976
3853977
3853978
3853979
3853980
3853981
3853982
3853984
3853985
3853986
3853987
3853988
3853989
3853990
3853991
41836_at
8035156
A_23_P16132
A_23_P16139
GE63332
GE81631
GO:0003676
GO:0003723
GO:0005515
GO:0005654
GO:0005737
GO:0005783
GO:0006396
GO:0006874
GO:0007399
GO:0008285
GO:0016020
GO:0033017
GO:0043226
GO:0044325
GO:0048471
GO:0048856
GO:0051209
GO:0055085
GO:0070886
HMNXSV003034084
Hs.6430.0.S1_3p_a_at
Hs2.300452.1.S1_3p_at
Hs2.300452.1.S1_3p_s_at
Hs2.300452.1.S1_3p_x_at
ILMN_1798083
PH_hs_0024394
TC19002687.hg
U94836_at
Y08265_s_at
g11055968_3p_a_at
Participates
as a component of
U2 snRNP [nucleoplasm] (Homo sapiens)
U2 12S snRNP [nucleoplasm] (Homo sapiens)
Inferred To
cherp [nucleoplasm]
(Danio rerio)
cherp [nucleoplasm]
(Xenopus tropicalis)
Cherp [nucleoplasm]
(Mus musculus)
Cherp [nucleoplasm]
(Rattus norvegicus)
CHERP [nucleoplasm]
(Bos taurus)
CHERP [nucleoplasm]
(Canis familiaris)
CHERP [nucleoplasm]
(Gallus gallus)
CHERP [nucleoplasm]
(Sus scrofa)
Ghost homologue of CHERP [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CHERP [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of CHERP [nucleoplasm]
(Schizosaccharomyces pombe)
scaf6 [nucleoplasm]
(Drosophila melanogaster)
tag-65 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_006378.3
ENSEMBL
ENST00000546361
,
ENSP00000439856
OpenTargets
ENSG00000085872
HPA
ENSG00000085872-CHERP
PRO
Q8IWX8
Pharos - Targets
Q8IWX8
GlyGen
Q8IWX8
HMDB Protein
HMDBP07584
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26368 U2AF2
2
U2AF2 [nucleoplasm]
(R-HSA-71987)
5OHK15,276-U2AF2 [nucleoplasm]
(R-HSA-9630011)
0.618
3
UniProt:Q15637 SF1
1
SF1 [nucleoplasm]
(R-HSA-8865928)
0.582
6
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.556
3
UniProt:O43143 DHX15
1
DHX15 [nucleoplasm]
(R-HSA-5688097)
0.527
2
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
3
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.527
3
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.527
3
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
p-8Y-FGFR2 K660M [plasma membrane]
(R-HSA-2033300)
p-8Y-FGFR2 K660E [plasma membrane]
(R-HSA-2033298)
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-2071957)
p-8Y-FGFR2 W290C [plasma membrane]
(R-HSA-2029875)
p-8Y-FGFR2 S267P [plasma membrane]
(R-HSA-2029879)
p-8Y-FGFR2 [plasma membrane]
(R-HSA-2029874)
p-8Y-FGFR2 N549K [plasma membrane]
(R-HSA-2033306)
0.527
2
UniProt:P62241 RPS8
2
RPS8 [cytosol]
(R-HSA-72385)
RPS8 [nucleoplasm]
(R-HSA-6791203)
0.527
2
UniProt:Q8WUA2 PPIL4
1
PPIL4 [nucleoplasm]
(R-HSA-8952113)
0.519
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.508
2
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.508
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.483
2
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