Reactome | Me2-R108,R112-SNRPN [nucleoplasm]

Me2-R108,R112-SNRPN [nucleoplasm]

Stable Identifier

R-HSA-8865931

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small nuclear ribonucleoprotein-associated protein N, RSMN_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63162 SNRPN

Gene Names

SNRPN, HCERN3, SMN

Chain

chain:1-240

Reference Genes

BioGPS Gene:6638 SNRPN

BioGPS Gene:8926 SNRPN

COSMIC (genes):SNRPN SNRPN

CTD Gene:6638 SNRPN

CTD Gene:8926 SNRPN

dbSNP Gene:6638 SNRPN

dbSNP Gene:8926 SNRPN

ENSEMBL:ENSG00000128739 SNRPN

ENSEMBL_homo_sapiens_GENE:ENSG00000128739.23 SNRPN

HGNC:11164 SNRPN

KEGG Gene (Homo sapiens):6638 SNRPN

KEGG Gene (Homo sapiens):8926 SNRPN

Monarch:6638 SNRPN

Monarch:8926 SNRPN

NCBI Gene:6638 SNRPN

NCBI Gene:8926 SNRPN

OMIM:182279 SNRPN

UCSC:P63162 SNRPN

Reference Transcript

Other Identifiers

11735173_a_at

11741832_a_at

11754272_x_at

16798020

201522_3p_x_at

201522_PM_x_at

201522_x_at

206042_3p_x_at

206042_PM_x_at

206042_x_at

34842_at

3584444

3584445

3584446

3584451

3584452

3584453

3584455

3584459

3584460

3584462

3584467

3584471

3584474

3584480

3584483

3584484

3584485

3584494

3584495

3584496

3584497

3584499

3584501

3584503

3584504

3584505

3584506

3584507

3584508

6638

7981919

A_14_P128005

A_23_P77066

A_24_P347624

GE57513

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0005685

GO:0005686

GO:0005687

GO:0005737

GO:0008380

GO:0009725

GO:0016071

GO:0030532

GO:0043226

GO:0046540

GO:0071004

GO:0071013

GO:1990904

HMNXSV003045486

HMNXSV003057927

ILMN_1656537

ILMN_1660000

ILMN_1662019

ILMN_1693341

ILMN_2372082

J04615_at

PH_hs_0003392

g13027651_3p_s_at

g13027654_3p_s_at

Participates

as a member of

Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)

Inferred To

Me2-R108,R112-SNRPB [nucleoplasm] (Plasmodium falciparum)

smb1 [nucleoplasm] (Schizosaccharomyces pombe)

SNRPN [nucleoplasm] (Canis familiaris)

Snrpn [nucleoplasm] (Mus musculus)

Snrpn [nucleoplasm] (Rattus norvegicus)

SNRPB [nucleoplasm] (Gallus gallus)

SNRPB [nucleoplasm] (Sus scrofa)

snr-2 [nucleoplasm] (Caenorhabditis elegans)

SmB [nucleoplasm] (Drosophila melanogaster)

snrpb [nucleoplasm] (Danio rerio)

snrpb [nucleoplasm] (Dictyostelium discoideum)

snrpb [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

symmetric dimethyl-L-arginine at 108

Coordinate

108

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Name

symmetric dimethyl-L-arginine at 112

Coordinate

112

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Cross References

RefSeq

NP_073719.1, NP_003088.1, NP_073717.1, NP_073718.1, NP_005669.2, NP_073716.1

OpenTargets

ENSG00000128739

HPA

ENSG00000128739-SNRPN

GeneCards

P63162

Ensembl

ENSP00000375105, ENST00000642807, ENST00000554227, ENST00000577565, ENST00000645002, ENST00000400097, ENST00000400100, ENSP00000463458, ENSP00000495345, ENST00000346403, ENSP00000382972, ENSG00000128739, ENSP00000452342, ENSP00000382969, ENST00000390687, ENSP00000306223, ENSP00000494831

PRO

P63162

Pharos - Targets

P63162

Orphanet

15534

PDB

8TBP, 5MF9

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.669	4
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.669	4
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	3
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.527	3
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.527	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.527	3
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.527	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.527	4
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	3
UniProt:Q9H875 PRKRIP1	1	PRKRIP1 [nucleoplasm] (R-HSA-9769594)	0.527	2
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [cytosol] (R-HSA-192217)	0.527	3
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.527	3
UniProt:Q9H5Z1 DHX35	1	DHX35 [nucleoplasm] (R-HSA-9770427)	0.527	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	2
UniProt:O75563 SKAP2	1	SKAP2 [cytosol] (R-HSA-390927)	0.527	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.527	3
UniProt:O75554 WBP4	1	WBP4 [nucleoplasm] (R-HSA-8867895)	0.527	2
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.527	3
UniProt:Q9BRR8 GPATCH1	1	GPATCH1 [nucleoplasm] (R-HSA-9770419)	0.527	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	2
UniProt:O95149 SNUPN	1	SNUPN [cytosol] (R-HSA-191857)	0.527	3
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	6