Reactome | CWC22 [nucleoplasm]

CWC22 [nucleoplasm]

Stable Identifier

R-HSA-8865956

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor CWC22 homolog, CWC22_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P21741 MDK

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External Reference Information

External Reference

UniProt:Q9HCG8 CWC22

Gene Names

CWC22, KIAA1604, NCM

Chain

chain:1-908

Reference Genes

BioGPS Gene:57703 CWC22

COSMIC (genes):CWC22 CWC22

CTD Gene:57703 CWC22

dbSNP Gene:57703 CWC22

ENSEMBL:ENSG00000163510 CWC22

HGNC:29322 CWC22

KEGG:hsa:57703 CWC22

Monarch:57703 CWC22

NCBI Gene:57703 CWC22

OMIM:615186 CWC22

UCSC:Q9HCG8 CWC22

Reference Transcript

Other Identifiers

11720955_x_at

11754743_a_at

16906065

226588_PM_at

226588_at

2590195

2590196

2590197

2590198

2590199

2590200

2590201

2590202

2590203

2590205

2590206

2590207

2590212

2590213

2590214

2590215

2590216

2590217

2590218

2590219

2590220

2590225

2590227

2590228

2590229

2590230

2590232

2590237

2590239

2590240

42003_at

43959_at

57703

8057441

86962_at

A_23_P373799

GE87393

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0048024

GO:0071005

GO:0071006

GO:0071007

GO:0071013

HMNXSV003012525

Hs.209464.0.A1_3p_at

ILMN_1674128

PH_hs_0023723

TC02002582.hg

Participates

as an input of

Formation of the Spliceosomal Bact complex (Homo sapiens)

as a component of

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Inferred To

cwc22 [nucleoplasm] (Danio rerio)

cwc22 [nucleoplasm] (Xenopus tropicalis)

ncm [nucleoplasm] (Drosophila melanogaster)

Cwc22 [nucleoplasm] (Mus musculus)

Cwc22 [nucleoplasm] (Rattus norvegicus)

cwf22 [nucleoplasm] (Schizosaccharomyces pombe)

let-858 [nucleoplasm] (Caenorhabditis elegans)

CWC22 [nucleoplasm] (Bos taurus)

CWC22 [nucleoplasm] (Canis familiaris)

CWC22 [nucleoplasm] (Dictyostelium discoideum)

CWC22 [nucleoplasm] (Gallus gallus)

CWC22 [nucleoplasm] (Plasmodium falciparum)

CWC22 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_065994.1, NP_001362958.1, XP_005246783.1, NP_001362959.1

ENSEMBL

ENSP00000387006, ENST00000410053, ENSG00000163510

OpenTargets

ENSG00000163510

HPA

ENSG00000163510-CWC22

GeneCards

CWC22

PRO

Q9HCG8

Pharos - Targets

Q9HCG8

GlyGen

Q9HCG8

PDB

4C9B, 7W59, 7A5P, 6FF7, 5Z58, 7DVQ, 8I0T, 5XJC, 7W5B, 6QDV, 7W5A, 5MQF, 6ICZ, 5Z56, 5Z57, 9FMD, 8I0U, 8I0S, 8CH6, 7QTT, 8I0V, 8I0R, 6YVH, 6ZYM, 8C6J, 8I0W, 5YZG

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.858	7
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.643	3
UniProt:Q8NCB2 CAMKV			0.643	3
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.643	3
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.556	3
UniProt:Q16825 PTN21			0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	2
UniProt:P55075 FGF8	1	FGF8 [nucleoplasm] (R-HSA-9832997)	0.527	2
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.527	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.527	2
UniProt:Q8N9I0 SYT2	3	SYT2 [synaptic vesicle membrane] (R-HSA-194786) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116)	0.527	2
UniProt:Q8IZU1 FAM9A			0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	3
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.527	2
UniProt:Q8N0W7 FMR1N			0.527	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.527	2
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.527	3
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	4
UniProt:Q9H4G0 EPB41L1	2	EPB41L1 [cytosol] (R-HSA-392241) EPB41L1 [plasma membrane] (R-HSA-416333)	0.527	2
UniProt:O14595 CTDSP2	1	CTDSP2 [nucleoplasm] (R-HSA-535488)	0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.527	2
UniProt:Q96PL5 ERMAP			0.527	3
UniProt:Q14331 FRG1			0.508	2
UniProt:Q9Y421 FAM32A	1	FAM32A [nucleoplasm] (R-HSA-9769598)	0.508	2

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