Interaction between beta-arrestins and components of the clathrin-coat mediate the recruitment of GPCRs into nascent clathrin-coated pits (Shenoy et al, 2001; Goodman et al, 1997; Goodman et al, 1997; Laporte et al, 1999; reviewed in Gurevich and Gurevich, 2006). In the case of the V2 vasopressin receptor (AVPR2) and the beta-2 adrenergic receptor (ADRB2), this beta-arrestin-mediated recruitment into clathrin-coated pits is negatively regulated by UBQLN2, possibly through competition for binding to the UIM-containing proteins such as EPS15, EPN1 and EPN2 (N'Diaye et al, 2008).
Goodman, OB, Krupnick, JG, Gurevich, VV, Benovic, JL, Keen, JH
N'Diaye, EN, Hanyaloglu, AC, Kajihara, KK, Puthenveedu, MA, Wu, P, von Zastrow, M, Brown, EJ
Shenoy, SK, McDonald, PH, Kohout, TA, Lefkowitz, RJ
Gurevich, VV, Gurevich, EV
Laporte, SA, Oakley, RH, Zhang, J, Holt, JA, Ferguson, SS, Caron, MG, Barak, LS
Goodman, OB, Krupnick, JG, Santini, F, Gurevich, VV, Penn, RB, Gagnon, AW, Keen, JH, Benovic, JL
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