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What is Reactome ?
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Digital Preservation
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POLE3 [nucleoplasm]
Stable Identifier
R-HSA-8866685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA polymerase epsilon subunit 3 ecNumber2.7.7.7/ecNumber, DPOE3_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
POLE3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRF9 POLE3
Gene Names
POLE3, CHRAC17
Chain
initiator methionine:, chain:2-147
Reference Genes
BioGPS Gene:54107 POLE3
COSMIC (genes):POLE3 POLE3
CTD Gene:54107 POLE3
dbSNP Gene:54107 POLE3
ENSEMBL:ENSG00000148229 POLE3
HGNC:13546 POLE3
KEGG:hsa:54107 POLE3
Monarch:54107 POLE3
NCBI Gene:54107 POLE3
OMIM:607267 POLE3
UCSC:Q9NRF9 POLE3
Reference Transcript
RefSeq:NM_001278255.1 POLE3
RefSeq:NM_017443.4 POLE3
Other Identifiers
11755956_x_at
11763496_a_at
11763497_x_at
11763572_s_at
17097495
208828_PM_at
208828_at
3221645
3221647
3221648
3221649
3221650
3221651
3221652
3221653
3221654
3221655
3221656
3221657
3221658
3221659
3221660
3221661
38702_at
54107
8163525
A_23_P135326
GE54666
GO:0000122
GO:0003677
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005654
GO:0005721
GO:0006260
GO:0006261
GO:0006272
GO:0006275
GO:0006325
GO:0006334
GO:0006338
GO:0006355
GO:0006974
GO:0008622
GO:0008623
GO:0016740
GO:0031490
GO:0031507
GO:0043226
GO:0046982
GO:0065003
GO:0071897
GO:0140097
GO:0140672
HMNXSV003055275
ILMN_1785198
PH_hs_0005994
TC09001503.hg
TC09002753.hg
g13278800_3p_at
g13278800_3p_x_at
Participates
as a component of
DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
Inferred To
POLE3 [nucleoplasm]
(Bos taurus)
POLE3 [nucleoplasm]
(Caenorhabditis elegans)
POLE3 [nucleoplasm]
(Canis familiaris)
POLE3 [nucleoplasm]
(Gallus gallus)
POLE3 [nucleoplasm]
(Plasmodium falciparum)
POLE3 [nucleoplasm]
(Sus scrofa)
pole3 [nucleoplasm]
(Dictyostelium discoideum)
pole3 [nucleoplasm]
(Xenopus tropicalis)
DPB4 [nucleoplasm]
(Saccharomyces cerevisiae)
Chrac-14 [nucleoplasm]
(Drosophila melanogaster)
dpb4 [nucleoplasm]
(Schizosaccharomyces pombe)
Pole3 [nucleoplasm]
(Mus musculus)
Pole3 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001265184.1
,
NP_059139.3
ENSEMBL
ENST00000374171
,
ENST00000374169
,
ENSP00000363286
,
ENSP00000363284
OpenTargets
ENSG00000148229
HPA
ENSG00000148229-POLE3
PRO
Q9NRF9
Pharos - Targets
Q9NRF9
GlyGen
Q9NRF9
HMDB Protein
HMDBP00966
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.781
7
UniProt:O60264 SMARCA5
1
SMARCA5 [nucleoplasm]
(R-HSA-417140)
0.527
3
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