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WDR61 [nucleoplasm]
Stable Identifier
R-HSA-8866696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WD repeat-containing protein 61, WDR61_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
WDR61 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZS3 SKIC8
Gene Names
SKIC8, WDR61
Chain
chain:1-305, initiator methionine:, chain:2-305
Reference Genes
BioGPS Gene:80349 SKIC8
CTD Gene:80349 SKIC8
dbSNP Gene:80349 SKIC8
ENSEMBL:ENSG00000140395 WDR61
ENSEMBL_homo_sapiens_GENE:ENSG00000140395.9 SKIC8
HGNC:30300 SKIC8
KEGG Gene (Homo sapiens):80349 SKIC8
Monarch:80349 SKIC8
NCBI Gene:80349 SKIC8
OMIM:609540 SKIC8
UCSC:Q9GZS3 SKIC8
Reference Transcript
RefSeq:NM_025234.2 SKIC8
RefSeq:XM_011522094.1 SKIC8
RefSeq:NM_001303247.1 SKIC8
RefSeq:NM_001303248.1 SKIC8
Other Identifiers
11757639_a_at
16812142
221531_at
221532_PM_s_at
221532_s_at
232075_PM_at
232075_at
3634595
3634596
3634597
3634599
3634602
3634604
3634606
3634607
3634608
3634612
3634613
3634616
3634619
3634621
3634622
3634625
3634626
7990700
80349
90320_at
GE56402
GE79470
GO:0000791
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006368
GO:0016055
GO:0016071
GO:0016593
GO:0023052
GO:0030154
GO:0036211
GO:0043226
GO:0045638
GO:0048856
GO:0051568
GO:0055087
GO:0070478
GO:0072344
HMNXSV003009479
Hs.306765.0.S1_3p_at
ILMN_1665887
PH_hs_0022380
TC15001703.hg
g11139241_3p_s_at
Participates
as a component of
PAF1C [nucleoplasm] (Homo sapiens)
Other forms of this molecule
WDR61 [cytosol]
Inferred To
SKIC8 [nucleoplasm]
(Bos taurus)
SKIC8 [nucleoplasm]
(Sus scrofa)
skic8 [nucleoplasm]
(Danio rerio)
skic8 [nucleoplasm]
(Dictyostelium discoideum)
skic8 [nucleoplasm]
(Xenopus tropicalis)
SKI8 [nucleoplasm]
(Saccharomyces cerevisiae)
rec14 [nucleoplasm]
(Schizosaccharomyces pombe)
Skic8 [nucleoplasm]
(Mus musculus)
Skic8 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG3909 [nucleoplasm]
(Drosophila melanogaster)
WDR61 [nucleoplasm]
(Caenorhabditis elegans)
WDR61 [nucleoplasm]
(Canis familiaris)
WDR61 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_001290176.1
,
XP_011520396.1
,
NP_079510.1
,
NP_001290177.1
HPA
ENSG00000140395-SKIC8
GeneCards
Q9GZS3
Ensembl
ENST00000558311
,
ENSG00000140395
,
ENST00000267973
,
ENSP00000267973
,
ENSP00000453801
PRO
Q9GZS3
Pharos - Targets
Q9GZS3
Orphanet
28708
PDB
7QDZ
,
6TED
,
7QDY
,
6GMH
,
7OPD
,
7OPC
,
7UNC
,
7QDR
,
7QDS
,
7UND
,
3OW8
,
7OOP
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.871
11
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
22
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.643
5
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:Q99497 PARK7
7
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PARK7 [nucleoplasm]
(R-HSA-3900141)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:P51149 RAB7A
7
RAB7A [secretory granule membrane]
(R-HSA-6804969)
RAB7A [plasma membrane]
(R-HSA-6804990)
RAB7A [cytosol]
(R-HSA-8870415)
RAB7A [phagocytic vesicle membrane]
(R-HSA-9636586)
RAB7A [lysosomal membrane]
(R-HSA-2213231)
GGC-RAB7A [cytosol]
(R-HSA-8870438)
GGC-RAB7A [lysosomal membrane]
(R-HSA-8877454)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P02545-2 LMNA
5
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.556
3
UniProt:P29474 NOS3
7
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
0.556
3
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