Reactome | Polyglutamyl-TUBB8 [cytosol]

Polyglutamyl-TUBB8 [cytosol]

Stable Identifier

R-HSA-8867387

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB8, Tubulin beta-8 chain, TBB8_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB8 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB8 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q3ZCM7 TUBB8

Gene Names

TUBB8

Chain

chain:1-444

Reference Genes

BioGPS Gene:347688 TUBB8

COSMIC (genes):TUBB8 TUBB8

CTD Gene:347688 TUBB8

dbSNP Gene:347688 TUBB8

ENSEMBL:ENSG00000261456 TUBB8

ENSEMBL_homo_sapiens_GENE:ENSG00000261456.6 TUBB8

HGNC:20773 TUBB8

KEGG Gene (Homo sapiens):347688 TUBB8

Monarch:347688 TUBB8

NCBI Gene:347688 TUBB8

OMIM:616768 TUBB8

UCSC:Q3ZCM7 TUBB8

Reference Transcript

RefSeq:NM_177987.2 TUBB8

Other Identifiers

11715155_s_at

11759454_a_at

11759455_s_at

11759456_x_at

2660087

2660089

2660093

2798367

2798368

3195776

3195777

3273180

3273181

3273182

3273183

3273184

3273185

3273186

3273187

3273188

3273189

3273192

347688

3674543

3674548

3795635

3795636

3795639

3795643

4030867

4035490

4050502

7931674

8021919

A_32_P16315

A_33_P3371333

GE82489

GO:0000166

GO:0000226

GO:0000278

GO:0001556

GO:0003674

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005819

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007056

GO:0007059

GO:0015630

GO:0016787

GO:0022414

GO:0030154

GO:0043226

GO:0045171

GO:0046872

GO:0048856

GO:0070062

GO:0072686

GO:0072687

GO:0140013

HMNXSV003036833

ILMN_2178994

PH_hs_0034781

TC10000959.hg

Participates

as a candidate of

Polyglutamyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

Polyglycyl-TUBB8 [cytosol]

TUBB8 [cytosol]

Inferred To

tubb2b [cytosol] (Xenopus tropicalis)

Polyglutamyl-TUBB8 [cytosol] (Mus musculus)

Polyglutamyl-TUBB8 [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBB4A [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBB4A [cytosol] (Plasmodium falciparum)

TUBB2B [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_817124.1

Guide to Pharmacology - Targets

2753

OpenTargets

ENSG00000261456

GeneCards

Q3ZCM7

HPA

ENSG00000261456-TUBB8

Ensembl

ENSG00000261456, ENSP00000456206, ENST00000568584

PRO

Q3ZCM7

Pharos - Targets

Q3ZCM7

Orphanet

25854

HMDB Protein

HMDBP08605