Reactome | Polyglutamyl-TUBB6 [cytosol]

Polyglutamyl-TUBB6 [cytosol]

Stable Identifier

R-HSA-8867399

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB6, beta tubulin 6

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB6 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB6 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BUF5 TUBB6

Gene Names

TUBB6

Chain

chain:1-446

Reference Genes

BioGPS Gene:84617 TUBB6

COSMIC (genes):TUBB6 TUBB6

CTD Gene:84617 TUBB6

dbSNP Gene:84617 TUBB6

ENSEMBL:ENSG00000176014 TUBB6

ENSEMBL_homo_sapiens_GENE:ENSG00000176014.13 TUBB6

HGNC:20776 TUBB6

KEGG Gene (Homo sapiens):84617 TUBB6

Monarch:84617 TUBB6

NCBI Gene:84617 TUBB6

OMIM:615103 TUBB6

UCSC:Q9BUF5 TUBB6

Reference Transcript

Other Identifiers

11715932_s_at

11747072_s_at

16851081

209191_PM_at

209191_at

2916784

33678_i_at

3779580

3779581

3779583

3779584

3779591

3779592

3779593

43355_s_at

8020220

84617

A_23_P254271

A_24_P313756

GE61273

GO:0000166

GO:0000226

GO:0000278

GO:0003674

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0043226

GO:0045171

GO:0046872

GO:0070062

GO:0072686

HMNXSV003052532

ILMN_1699489

ILMN_1702636

PH_hs_0014153

g12803638_3p_at

Participates

as a candidate of

Polyglutamyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB6 [cytosol]

TUBB6 [axonemal microtubule]

Polyglycyl-TUBB6 [cytosol]

TUBB6 unfolded [cytosol]

TUBB6 folding intermediate [cytosol]

Inferred To

tubb6 [cytosol] (Xenopus tropicalis)

Polyglutamyl-TUBB6 [cytosol] (Bos taurus)

Polyglutamyl-TUBB6 [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBB6 [cytosol] (Mus musculus)

Polyglutamyl-TUBB6 [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBB6 [cytosol] (Rattus norvegicus)

TUBB6 [cytosol] (Canis familiaris)

TUBB6 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_001290455.1, NP_001290457.1, NP_001290454.1, NP_001290458.1, NP_001290453.1, NP_001290459.1, NP_115914.1, NP_001290456.1

OpenTargets

ENSG00000176014

HPA

ENSG00000176014-TUBB6

GeneCards

Q9BUF5

Ensembl

ENSG00000176014, ENST00000317702, ENSP00000318697

PRO

Q9BUF5

Pharos - Targets

Q9BUF5

HMDB Protein

HMDBP08049

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	20
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.547	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3

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