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Polyglutamyl-TUBB4B [cytosol]
Stable Identifier
R-HSA-8867427
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TUBB4B, beta tubulin 2C
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB4B [cytosol] (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB4B [cytosol] (Homo sapiens)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB4B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68371 TUBB4B
Gene Names
TUBB4B, TUBB2C
Chain
chain:1-445
Reference Genes
BioGPS Gene:10383 TUBB4B
COSMIC (genes):TUBB4B TUBB4B
CTD Gene:10383 TUBB4B
dbSNP Gene:10383 TUBB4B
ENSEMBL:ENSG00000188229 TUBB4B
ENSEMBL_homo_sapiens_GENE:ENSG00000188229.6 TUBB4B
HGNC:20771 TUBB4B
KEGG Gene (Homo sapiens):10383 TUBB4B
Monarch:10383 TUBB4B
NCBI Gene:10383 TUBB4B
OMIM:602660 TUBB4B
UCSC:P68371 TUBB4B
Reference Transcript
RefSeq:NM_006088.5 TUBB4B
Other Identifiers
10383
11750415_x_at
11755974_s_at
17091695
208977_PM_x_at
208977_x_at
213726_PM_x_at
213726_x_at
33678_i_at
33679_f_at
3988357
4050498
4050501
4050502
4050503
4050504
4050505
4050506
4050507
4050508
4050509
8159642
90051_at
956_at
A_23_P312863
GE61196
GO:0000166
GO:0000226
GO:0000278
GO:0002376
GO:0003723
GO:0003725
GO:0003824
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005856
GO:0005874
GO:0005879
GO:0005929
GO:0007010
GO:0007017
GO:0015630
GO:0016787
GO:0031410
GO:0035578
GO:0042267
GO:0042288
GO:0043226
GO:0045171
GO:0046872
GO:0051082
GO:0070062
GO:0072686
GO:0098542
GO:1903561
HMNXSV003036833
Hs.251653.1.A1_3p_x_at
ILMN_1780769
PH_hs_0033325
TC09000844.hg
g13278848_3p_a_at
Participates
as a candidate of
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
TUBB4B [cytosol]
TUBB4B [azurophil granule lumen]
TUBB4B [extracellular region]
TUBB4B [axonemal microtubule]
Polyglycyl-TUBB4B [cytosol]
TUBB4B unfolded [cytosol]
TUBB4B folding intermediate [cytosol]
Inferred To
Polyglutamyl-TUBB4B [cytosol]
(Bos taurus)
Polyglutamyl-TUBB4B [cytosol]
(Mus musculus)
Polyglutamyl-TUBB4B [cytosol]
(Rattus norvegicus)
TUBB4B [cytosol]
(Canis familiaris)
TUBB4B [cytosol]
(Sus scrofa)
Polyglutamyl-TUBB2A [cytosol]
(Dictyostelium discoideum)
Polyglutamyl-TUBB2A [cytosol]
(Plasmodium falciparum)
tubb4a [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
L-isoglutamyl-polyglutamic acid at unknown position
PsiMod Name
L-isoglutamyl-polyglutamic acid
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.
Cross References
RefSeq
NP_006079.1
Guide to Pharmacology - Targets
2641
OpenTargets
ENSG00000188229
ZINC - Substances
TBB4B_HUMAN
ZINC target
P68371
PRO
P68371
PDB
7UN1
,
8J07
,
7UNG
HPA
ENSG00000188229-TUBB4B
GeneCards
P68371
Ensembl
ENSP00000341289
,
ENST00000340384
,
ENSG00000188229
Pharos - Targets
P68371
Orphanet
28876
HMDB Protein
HMDBP08046
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.547
3
UniProt:Q15398 DLGAP5
1
DLGAP5 [cytosol]
(R-HSA-264452)
0.527
2
UniProt:P36404 ARL2
2
ARL2 [cytosol]
(R-HSA-5216230)
ARL2 [mitochondrial matrix]
(R-HSA-5250216)
0.527
4
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
2
UniProt:Q07954 LRP1
2
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
0.527
2
UniProt:Q9BTW9 TBCD
1
TBCD [cytosol]
(R-HSA-379540)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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