PICALM binds R-SNAREs

Stable Identifier
R-HSA-8867613
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PICALM is a phosphatidylinositol-binding clathrin assembly protein that interacts with PI(4,5)P2 and clathrin and plays a role in recruiting clathrin and AP-2 to nascent coated pits at the plasma membrane (Tebar et al, 1999). In addition, PICALM binds directly to a number of R-SNAREs, including VAMP2,3 and 8 to mediate their inclusion in clathrin-coated pits and subsequent recycling to the endosome where they function (Miller et al, 2011).
Literature References
PubMed ID Title Journal Year
22118466 The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM

Miller, SE, Höning, S, Owen, DJ, Robinson, MS, Sahlender, DA, Peden, AA, Graham, SC

Cell 2011
10436022 Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic

Tebar, F, Sorkin, A, Bohlander, SK

Mol. Biol. Cell 1999
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