Reactome | SH3GL3 [cytosol]

SH3GL3 [cytosol]

Stable Identifier

R-HSA-8867734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Endophilin-A3, SH3G3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q99961 SH3GL1

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        ARC binds DNM2 and SH3GL3 (Homo sapiens)
        
        SH3GL3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99963 SH3GL3

Gene Names

SH3GL3, CNSA3, SH3D2C

Chain

chain:1-347

Reference Genes

BioGPS Gene:6457 SH3GL3

COSMIC (genes):SH3GL3 SH3GL3

CTD Gene:6457 SH3GL3

dbSNP Gene:6457 SH3GL3

ENSEMBL:ENSG00000140600 SH3GL3

ENSEMBL_homo_sapiens_GENE:ENSG00000140600.17 SH3GL3

ENSEMBL_homo_sapiens_GENE:ENSG00000291608.1 SH3GL3

HGNC:10832 SH3GL3

KEGG Gene (Homo sapiens):6457 SH3GL3

Monarch:6457 SH3GL3

NCBI Gene:6457 SH3GL3

OMIM:603362 SH3GL3

UCSC:Q99963 SH3GL3

Reference Transcript

Other Identifiers

11733179_a_at

11758651_s_at

16804081

205637_PM_s_at

205637_s_at

3605347

3605349

3605350

3605354

3605355

3605357

3605358

3605365

3605367

3605368

3605369

3605371

3605378

3605380

3605393

3605394

37580_at

6457

7985507

A_14_P133302

A_23_P48988

GE80470

GO:0001669

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0006897

GO:0007165

GO:0007417

GO:0008289

GO:0016020

GO:0016191

GO:0016192

GO:0023052

GO:0030154

GO:0031410

GO:0031901

GO:0042802

GO:0043226

GO:0045666

GO:0048856

GO:0098793

GO:0098845

GO:0098978

GO:0099092

GO:1900186

GO:2000369

HMNXSV003015421

HMNXSV003020512

ILMN_1760990

PH_hs_0023335

TC15000798.hg

TC15002329.hg

X99664_at

g4506932_3p_a_at

Participates

as a component of

as an input of

ARC binds DNM2 and SH3GL3 (Homo sapiens)

Inferred To

EndoA [cytosol] (Drosophila melanogaster)

SH3GL3 [cytosol] (Bos taurus)

SH3GL3 [cytosol] (Dictyostelium discoideum)

SH3GL3 [cytosol] (Gallus gallus)

SH3GL3 [cytosol] (Schizosaccharomyces pombe)

SH3GL3 [cytosol] (Sus scrofa)

sh3gl3 [cytosol] (Xenopus tropicalis)

Sh3gl3 [cytosol] (Mus musculus)

Sh3gl3 [cytosol] (Rattus norvegicus)

sh3gl3a [cytosol] (Danio rerio)

unc-57 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001288037.1, NP_001311112.1, NP_001311116.1, NP_003018.3, NP_001288038.1, NP_001311114.1, XP_011520191.1, XP_016877975.1

OpenTargets

ENSG00000140600

HPA

ENSG00000140600-SH3GL3

GeneCards

Q99963

Ensembl

ENST00000427482, ENSP00000391372, ENSP00000320092, ENSG00000140600, ENST00000324537

PRO

Q99963

Pharos - Targets

Q99963

PDB

2Z0V, 2EW3

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.835	7
UniProt:Q99700 ATX2			0.756	11
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.743	9
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.721	7
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.691	4
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.635	3
UniProt:Q70E73 RAPH1			0.626	4
UniProt:P18077 RPL35A	1	RPL35A [cytosol] (R-HSA-72462)	0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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