Reactome | CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

Stable Identifier

R-HSA-8867756

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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CLASP proteins are recruited to nascent clathrin-coated pits (CCPs) through interactions with AP-2 and clathrin. Although in this pathway cargo recruitment is depicted as occuring after the recruitment of bulk AP-2 and clathrin, a number of studies suggest that they are largely recruited concomitantly (Liu et al, 2010; reviewed in McMahon and Boucrot, 2011). Concurrent interactions with sorting signals in cargo cytoplasmic tails and with clathrin and/or AP-2 ensure that CLASPs and cargo are incorporated into the emerging CCP (Schmid et al, 2006; Edeling et al, 2006; reviewed in Traub, 2009; Traub and Bonifacino, 2013; Kirchausen et al, 2014). In addition, incorporation of CLASPs and cargo may play a role in regulating the timing and dynamics of endocytosis (Loerke et al, 2009; Mettlen et al, 2009; Soohoo et al, 2013; Mettlen et al, 2010; Puthenveedu et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16516836	Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly Edeling, MA, Mishra, SK, Keyel, PA, Steinhauser, AL, Collins, BM, Roth, R, Heuser, JE, Owen, DJ, Traub, LM	Dev. Cell	2006
19458185	Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits Mettlen, M, Stoeber, M, Loerke, D, Antonescu, CN, Danuser, G, Schmid, SL	Mol. Biol. Cell	2009
21779028	Molecular mechanism and physiological functions of clathrin-mediated endocytosis McMahon, HT, Boucrot, E	Nat. Rev. Mol. Cell Biol.	2011
21187331	Local clustering of transferrin receptors promotes clathrin-coated pit initiation Liu, AP, Aguet, F, Danuser, G, Schmid, SL	J. Cell Biol.	2010
24789820	Molecular structure, function, and dynamics of clathrin-mediated membrane traffic Kirchhausen, T, Owen, D, Harrison, SC	Cold Spring Harb Perspect Biol	2014
19296720	Cargo and dynamin regulate clathrin-coated pit maturation Loerke, D, Mettlen, M, Yarar, D, Jaqaman, K, Jaqaman, H, Danuser, G, Schmid, SL	PLoS Biol.	2009
24186068	Cargo recognition in clathrin-mediated endocytosis Traub, LM, Bonifacino, JS	Cold Spring Harb Perspect Biol	2013
17018281	Cargo regulates clathrin-coated pit dynamics Puthenveedu, MA, von Zastrow, M	Cell	2006
19696796	Tickets to ride: selecting cargo for clathrin-regulated internalization Traub, LM	Nat. Rev. Mol. Cell Biol.	2009
20231386	Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis Mettlen, M, Loerke, D, Yarar, D, Danuser, G, Schmid, SL	J. Cell Biol.	2010
16903783	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT	PLoS Biol.	2006
23536704	Divergent modes for cargo-mediated control of clathrin-coated pit dynamics Soohoo, AL, Puthenveedu, MA	Mol. Biol. Cell	2013