Reactome | CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

Stable Identifier

R-HSA-8867756

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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CLASP proteins are recruited to nascent clathrin-coated pits (CCPs) through interactions with AP-2 and clathrin. Although in this pathway cargo recruitment is depicted as occuring after the recruitment of bulk AP-2 and clathrin, a number of studies suggest that they are largely recruited concomitantly (Liu et al, 2010; reviewed in McMahon and Boucrot, 2011). Concurrent interactions with sorting signals in cargo cytoplasmic tails and with clathrin and/or AP-2 ensure that CLASPs and cargo are incorporated into the emerging CCP (Schmid et al, 2006; Edeling et al, 2006; reviewed in Traub, 2009; Traub and Bonifacino, 2013; Kirchausen et al, 2014). In addition, incorporation of CLASPs and cargo may play a role in regulating the timing and dynamics of endocytosis (Loerke et al, 2009; Mettlen et al, 2009; Soohoo et al, 2013; Mettlen et al, 2010; Puthenveedu et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16516836	Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly Steinhauser, AL, Keyel, PA, Edeling, MA, Owen, DJ, Heuser, JE, Mishra, SK, Traub, LM, Collins, BM, Roth, R	Dev. Cell	2006
19458185	Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits Stoeber, M, Loerke, D, Antonescu, CN, Mettlen, M, Danuser, G, Schmid, SL	Mol. Biol. Cell	2009
21779028	Molecular mechanism and physiological functions of clathrin-mediated endocytosis Boucrot, E, McMahon, HT	Nat. Rev. Mol. Cell Biol.	2011
21187331	Local clustering of transferrin receptors promotes clathrin-coated pit initiation Liu, AP, Aguet, F, Danuser, G, Schmid, SL	J. Cell Biol.	2010
24789820	Molecular structure, function, and dynamics of clathrin-mediated membrane traffic Owen, D, Kirchhausen, T, Harrison, SC	Cold Spring Harb Perspect Biol	2014
19296720	Cargo and dynamin regulate clathrin-coated pit maturation Jaqaman, H, Yarar, D, Loerke, D, Jaqaman, K, Mettlen, M, Danuser, G, Schmid, SL	PLoS Biol.	2009
24186068	Cargo recognition in clathrin-mediated endocytosis Traub, LM, Bonifacino, JS	Cold Spring Harb Perspect Biol	2013
17018281	Cargo regulates clathrin-coated pit dynamics Puthenveedu, MA, von Zastrow, M	Cell	2006
19696796	Tickets to ride: selecting cargo for clathrin-regulated internalization Traub, LM	Nat. Rev. Mol. Cell Biol.	2009
20231386	Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis Yarar, D, Loerke, D, Mettlen, M, Danuser, G, Schmid, SL	J. Cell Biol.	2010
16903783	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly McMahon, HT, Ford, MG, Praefcke, GJ, Benmerah, A, Burtey, A, Peak-Chew, SY, Schmid, EM, Mills, IG	PLoS Biol.	2006
23536704	Divergent modes for cargo-mediated control of clathrin-coated pit dynamics Soohoo, AL, Puthenveedu, MA	Mol. Biol. Cell	2013