Reactome | HIP1R [cytosol]

HIP1R [cytosol]

Stable Identifier

R-HSA-8868155

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Huntingtin-interacting protein 1-related protein, HIP1R_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        HIP1R dimer [cytosol] (Homo sapiens)
        
        HIP1R [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75146 HIP1R

Gene Names

HIP1R, HIP12, KIAA0655

Chain

chain:1-1068

Reference Genes

BioGPS Gene:9026 HIP1R

COSMIC (genes):HIP1R HIP1R

CTD Gene:9026 HIP1R

dbSNP Gene:9026 HIP1R

ENSEMBL:ENSG00000130787 HIP1R

ENSEMBL_homo_sapiens_GENE:ENSG00000130787.14 HIP1R

HGNC:18415 HIP1R

KEGG Gene (Homo sapiens):9026 HIP1R

Monarch:9026 HIP1R

NCBI Gene:9026 HIP1R

OMIM:605613 HIP1R

UCSC:O75146 HIP1R

Reference Transcript

Other Identifiers

11722493_s_at

11722494_s_at

11750828_a_at

16758463

209558_PM_s_at

209558_s_at

209559_PM_at

209559_at

3040880

3435550

3435551

3435552

3435555

3435559

3435560

3435561

3435563

3435565

3435574

3435576

3435577

3435578

3435579

3435580

3435581

3435582

3435583

3435584

3435586

3435590

3435591

3435592

3435593

3435594

3435595

3435596

3435598

3435600

3435602

3435603

3435604

3435605

3435606

3435607

3435608

3435609

3435610

3435611

3435612

3435613

3435614

38340_PM_at

38340_at

7959500

9026

A_23_P398294

A_24_P229164

GE493990

GE53366

GO:0003779

GO:0005515

GO:0005543

GO:0005546

GO:0005547

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0005905

GO:0005938

GO:0006897

GO:0006898

GO:0006919

GO:0007005

GO:0007010

GO:0007015

GO:0008092

GO:0008289

GO:0012501

GO:0012505

GO:0014069

GO:0016020

GO:0016192

GO:0016324

GO:0017124

GO:0022600

GO:0023052

GO:0030100

GO:0030136

GO:0030276

GO:0030665

GO:0030837

GO:0031410

GO:0032051

GO:0032092

GO:0032587

GO:0032839

GO:0032956

GO:0034316

GO:0034330

GO:0035091

GO:0035615

GO:0042802

GO:0042803

GO:0043025

GO:0043065

GO:0043066

GO:0043197

GO:0043226

GO:0043231

GO:0043325

GO:0045742

GO:0046982

GO:0048268

GO:0048471

GO:0048856

GO:0050821

GO:0051015

GO:0055123

GO:0060090

GO:0060453

GO:0061024

GO:0065003

GO:0080025

GO:0097060

GO:0098794

GO:0098978

GO:0099173

GO:1901030

GO:1905445

GO:2000369

GO:2000588

HMNXSV003039180

ILMN_1711699

ILMN_1757910

ILMN_1812721

ILMN_2288402

ILMN_2396148

PH_hs_0031429

TC12000979.hg

g3721835_3p_a_at

g3721835_3p_s_at

Participates

as a component of

HIP1R dimer [cytosol] (Homo sapiens)

Other forms of this molecule

HIP1R [Golgi membrane]

HIP1R [cytoplasmic vesicle membrane]

Inferred To

end4 [cytosol] (Schizosaccharomyces pombe)

Hip1 [cytosol] (Drosophila melanogaster)

HIP1R [cytosol] (Bos taurus)

HIP1R [cytosol] (Canis familiaris)

HIP1R [cytosol] (Gallus gallus)

HIP1R [cytosol] (Sus scrofa)

Hip1r [cytosol] (Mus musculus)

Hip1r [cytosol] (Rattus norvegicus)

hipr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001290026.1, NP_003950.1

OpenTargets

ENSG00000130787

GeneCards

O75146

HPA

ENSG00000130787-HIP1R

Ensembl

ENST00000253083, ENSP00000253083, ENSG00000130787

PRO

O75146

Pharos - Targets

O75146

PDB

1R0D

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	3

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