Reactome | PACSIN2 [cytosol]

PACSIN2 [cytosol]

Stable Identifier

R-HSA-8868267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C and casein kinase substrate in neurons protein 2, PACN2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PACSIN dimers [cytosol] (Homo sapiens)
        
        PACSIN2 dimer [cytosol] (Homo sapiens)
        
        PACSIN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNF0 PACSIN2

Gene Names

PACSIN2

Chain

chain:1-486

Reference Genes

BioGPS Gene:11252 PACSIN2

COSMIC (genes):PACSIN2 PACSIN2

CTD Gene:11252 PACSIN2

dbSNP Gene:11252 PACSIN2

ENSEMBL:ENSG00000100266 PACSIN2

HGNC:8571 PACSIN2

Monarch:11252 PACSIN2

NCBI Gene:11252 PACSIN2

OMIM:604960 PACSIN2

UCSC:Q9UNF0 PACSIN2

Reference Transcript

Other Identifiers

11252

11735196_a_at

11745763_a_at

11759542_s_at

1554691_PM_a_at

1554691_a_at

16935724

16935727

201651_PM_s_at

201651_s_at

35886_at

3962650

3962651

3962655

3962675

3962679

3962680

3962683

3962684

3962685

3962689

3962690

3962691

3962692

3962693

3962703

3962704

3962714

3962715

3962717

3962718

3962719

3962720

3962725

3962727

57086_at

8076533

88092_at

A_23_P80377

A_33_P3314192

GE58442

GO:0005515

GO:0005543

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005886

GO:0005901

GO:0005911

GO:0005925

GO:0006897

GO:0007010

GO:0008092

GO:0008289

GO:0016192

GO:0016607

GO:0030036

GO:0030100

GO:0031410

GO:0032587

GO:0034451

GO:0036010

GO:0042802

GO:0042995

GO:0043226

GO:0043231

GO:0045296

GO:0045806

GO:0048858

GO:0050804

GO:0055038

GO:0061024

GO:0070062

GO:0070300

GO:0070836

GO:0072584

GO:0097320

GO:0098978

HMNXSV003019060

Hs2.18842.3.S1_3p_s_at

ILMN_1702396

PH_hs_0026307

g6005825_3p_a_at

Participates

as a component of

PACSIN2 dimer [cytosol] (Homo sapiens)

Inferred To

cdc15 [cytosol] (Schizosaccharomyces pombe)

sdpn-1 [cytosol] (Caenorhabditis elegans)

Homologues of PACSIN2 [cytosol] (Dictyostelium discoideum)

Homologues of PACSIN2 [cytosol] (Schizosaccharomyces pombe)

Pacsin2 [cytosol] (Mus musculus)

Pacsin2 [cytosol] (Rattus norvegicus)

mgp1 [cytosol] (Dictyostelium discoideum)

rga9 [cytosol] (Schizosaccharomyces pombe)

Synd [cytosol] (Drosophila melanogaster)

syp1 [cytosol] (Schizosaccharomyces pombe)

rga8 [cytosol] (Schizosaccharomyces pombe)

PACSIN2 [cytosol] (Bos taurus)

PACSIN2 [cytosol] (Canis familiaris)

PACSIN2 [cytosol] (Dictyostelium discoideum)

PACSIN2 [cytosol] (Gallus gallus)

PACSIN2 [cytosol] (Sus scrofa)

imp2 [cytosol] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENSP00000385372, ENST00000407585, ENSP00000385040, ENST00000403744, ENSP00000385952, ENST00000263246, ENST00000337959, ENSP00000338379, ENSP00000263246, ENST00000402229

OpenTargets

ENSG00000100266

HPA

ENSG00000100266-PACSIN2

PRO

Q9UNF0

Pharos - Targets

Q9UNF0

GlyGen

Q9UNF0

PDB

3ACO, 3ABH, 3Q0K, 3HAJ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.591	4
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.524	4

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